Measurements of optical properties of pig brain tissue in vitro using a novel compact device

Nazila Yavari, Jan Sorensen Dam, Johan Antonsson, Karin Wardell, Stefan Andersson-Engels

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingResearchpeer-review

1 Citation (Scopus)


In numerous medical and scientific fields, knowledge of the optical properties of tissues can be applied. Among many different ways of determining the optical properties of turbid media; integrating sphere measurements are widely used. However, this technique is associated with bulky equipment, complicated measuring techniques, interference compensation techniques, and inconvenient sample handling. This paper describes measurements of the optical properties of porcine brain tissue using novel instrumentation for simultaneous absorption and scattering characterization of small turbid samples. The system used measures both angularly and spatially resolved transmission and reflection and is called Combined Angular and Spatially-resolved Head (CASH) sensor. The results compare very well with data obtained with an integrating sphere for well-defined samples. The instrument was shown to be accurate to within 12 % for μ<sub>a</sub>. and 1 % for μ<sub>s</sub>' in measurements of intralipid-ink samples. The corresponding variations of data were 17 %, and 2 %, respectively. The reduced scattering coefficient for porcine white matter was measured to be 100 cm<sup>-1</sup>, while the value for coagulated brain tissue was 65 cm<sup>-1</sup>. The corresponding absorption coefficients were 2 and 3 cm<sup>-1</sup>, respectively. © 2005 SPIE and OSA.
Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherInternational Society for Optical Engineering
Publication statusPublished - 2005
EventNovel Optical Instrumentation for Biomedical Applications II - Munich, Germany
Duration: 2005 Jun 122005 Jun 16

Publication series

ISSN (Print)1042-4687
ISSN (Electronic)1605-7422


ConferenceNovel Optical Instrumentation for Biomedical Applications II

Subject classification (UKÄ)

  • Atom and Molecular Physics and Optics


  • Absorption coefficients
  • Pig brain tissue
  • Turbid media
  • Optical device


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