Measurements of the gastric emptying rate by use of ultrasonography: studies in humans using bread with added sodium propionate

Ghassan Darwiche, Elin Östman, Helena Elmståhl, Nina Kallinen, Ola Björgell, Inger Björck, Lars-Olof Almér

Research output: Contribution to journalArticlepeer-review

46 Citations (SciVal)

Abstract

Background: Foods with a low glycemic index are increasingly being acknowledged as beneficial for individuals with disorders related to the insulin resistance syndrome. The presence of certain salts of organic acids has been shown to lower the glycemic index of bread products and one of the suggested mechanisms is a lowered gastric emptying rate (GER). One obvious pitfall with many of the common techniques for GER measurement is that the food structure, and hence the gastric release of nutrients, may be affected by enclosure of the marker for gastric emptying, eg, paracetamol. Ultrasonography is a noninvasive method for which the above pitfall is to a large extent avoided.

Objective: The main objective was to evaluate the use of ultrasonography to determine whether the lowered glycemic and insulinemic responses to bread ingestion after the addition of sodium propionate are explained by a specific effect of propionate on the GER.

Design: The effect of sodium propionate in bread was evaluated in 9 healthy volunteers. Barley bread products, with or without added sodium propionate, were ingested as breakfast after an overnight fast. The GER was monitored for 2 h by ultrasonography; during this period, capillary blood was withdrawn repeatedly for measurement of blood glucose and insulin.

Results: The GER of the barley bread decreased markedly after the addition of sodium propionate and was accompanied by lowered glycemic and insulinemic responses.

Conclusion: The lowered glycemic response to ingestion of bread with added sodium propionate appears to be related to a lowered GER.
Original languageEnglish
Pages (from-to)254-258
JournalAmerican Journal of Clinical Nutrition
Volume74
Issue number2
Publication statusPublished - 2001

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300), Medical Radiology Unit (013241410), Internal Medicine (013242500), Hypertension and Cardiovascular Disease (013242540), Internal Medicine Research Unit (013242520)

Subject classification (UKÄ)

  • Nutrition and Dietetics

Keywords

  • sodium propionate
  • ultrasonography
  • glycemic index
  • gastric emptying rate
  • Glucose and insulin responses
  • healthy humans
  • bread
  • organic acids

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