Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Carlos A Gonzalez; Paula Jakszyn; Guillem Pera; Antonio Agudo; Sheila Bingham; Domenico Palli; Pietro Ferrari; Heiner Boeing; Giuseppe del Giudice; Mario Plebani; Fatima Carneiro; Gabriella Nesi; Franco Berrino; Carlotta Sacerdote; R Tumino; Salvatore Panico; Göran Berglund; Henrik Simán; Olof Nyrén; Carmen Martinez; Göran Hallmans; Miren Dorronsoro,; Aurelio Barricarte; Carmen Navarro; José R. Quirós; Naomi Allen; Timothy J. Key; Nicholas E. Day; Jakob Linseisen; Gabriele Nagel; Manuela M. Bergmann; Kim Overvad; Majken K. J ensen; Anne Tjonneland; Anja Olsen; H. Bas Bueno-de-Mesquita; Marga Ocke; Petra H. M. Peeters; Mattijs E. Numans; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Antonia Trichopoulou; Theodora Psaltopoulou; Dimitrios Roukos; Eiliv Lund; Bertrand Hemon; Rudolf Kaaks; Teresa Norat; Elio Riboli

doi:10.1093/jnci/djj071

Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Carlos A Gonzalez, Paula Jakszyn, Guillem Pera, Antonio Agudo, Sheila Bingham, Domenico Palli, Pietro Ferrari, Heiner Boeing, Giuseppe del Giudice, Mario Plebani, Fatima Carneiro, Gabriella Nesi, Franco Berrino, Carlotta Sacerdote, R Tumino, Salvatore Panico, Göran Berglund, Henrik Simán, Olof Nyrén, Carmen MartinezGöran Hallmans, Miren Dorronsoro,, Aurelio Barricarte, Carmen Navarro, José R. Quirós, Naomi Allen, Timothy J. Key, Nicholas E. Day, Jakob Linseisen, Gabriele Nagel, Manuela M. Bergmann, Kim Overvad, Majken K. J ensen, Anne Tjonneland, Anja Olsen, H. Bas Bueno-de-Mesquita, Marga Ocke, Petra H. M. Peeters, Mattijs E. Numans, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Antonia Trichopoulou, Theodora Psaltopoulou, Dimitrios Roukos, Eiliv Lund, Bertrand Hemon, Rudolf Kaaks, Teresa Norat, Elio Riboli

Internal Medicine - Epidemiology

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. METHODS: A total of 521,457 men and women aged 35-70 years in 10 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric non-cardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. RESULTS: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric non-cardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI = 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric non-cardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. CONCLUSION: Total, red, and processed meat intakes were associated with an increased risk of gastric non-cardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.

Original language	English
Pages (from-to)	345-354
Journal	Journal of the National Cancer Institute
Volume	98
Issue number	5
DOIs	https://doi.org/10.1093/jnci/djj071
Publication status	Published - 2006

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/jnci/djj071

Cite this

Gonzalez, C. A., Jakszyn, P., Pera, G., Agudo, A., Bingham, S., Palli, D., Ferrari, P., Boeing, H., del Giudice, G., Plebani, M., Carneiro, F., Nesi, G., Berrino, F., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Simán, H., Nyrén, O., ... Riboli, E. (2006). Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). Journal of the National Cancer Institute, 98(5), 345-354. https://doi.org/10.1093/jnci/djj071

@article{6730259c73894885ae9509d07a880fad,

title = "Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)",

abstract = "BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. METHODS: A total of 521,457 men and women aged 35-70 years in 10 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric non-cardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. RESULTS: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric non-cardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI = 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric non-cardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. CONCLUSION: Total, red, and processed meat intakes were associated with an increased risk of gastric non-cardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.",

author = "Gonzalez, {Carlos A} and Paula Jakszyn and Guillem Pera and Antonio Agudo and Sheila Bingham and Domenico Palli and Pietro Ferrari and Heiner Boeing and {del Giudice}, Giuseppe and Mario Plebani and Fatima Carneiro and Gabriella Nesi and Franco Berrino and Carlotta Sacerdote and R Tumino and Salvatore Panico and G{\"o}ran Berglund and Henrik Sim{\'a}n and Olof Nyr{\'e}n and Carmen Martinez and G{\"o}ran Hallmans and Miren Dorronsoro, and Aurelio Barricarte and Carmen Navarro and Quir{\'o}s, {Jos{\'e} R.} and Naomi Allen and Key, {Timothy J.} and Day, {Nicholas E.} and Jakob Linseisen and Gabriele Nagel and Bergmann, {Manuela M.} and Kim Overvad and ensen, {Majken K. J} and Anne Tjonneland and Anja Olsen and Bueno-de-Mesquita, {H. Bas} and Marga Ocke and Peeters, {Petra H. M.} and Numans, {Mattijs E.} and Fran{\c c}oise Clavel-Chapelon and Marie-Christine Boutron-Ruault and Antonia Trichopoulou and Theodora Psaltopoulou and Dimitrios Roukos and Eiliv Lund and Bertrand Hemon and Rudolf Kaaks and Teresa Norat and Elio Riboli",

year = "2006",

doi = "10.1093/jnci/djj071",

language = "English",

volume = "98",

pages = "345--354",

journal = "Journal of the National Cancer Institute",

issn = "1460-2105",

publisher = "Oxford University Press",

number = "5",

}

Gonzalez, CA, Jakszyn, P, Pera, G, Agudo, A, Bingham, S, Palli, D, Ferrari, P, Boeing, H, del Giudice, G, Plebani, M, Carneiro, F, Nesi, G, Berrino, F, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Simán, H, Nyrén, O, Martinez, C, Hallmans, G, Dorronsoro, M, Barricarte, A, Navarro, C, Quirós, JR, Allen, N, Key, TJ, Day, NE, Linseisen, J, Nagel, G, Bergmann, MM, Overvad, K, ensen, MKJ, Tjonneland, A, Olsen, A, Bueno-de-Mesquita, HB, Ocke, M, Peeters, PHM, Numans, ME, Clavel-Chapelon, F, Boutron-Ruault, M-C, Trichopoulou, A, Psaltopoulou, T, Roukos, D, Lund, E, Hemon, B, Kaaks, R, Norat, T & Riboli, E 2006, 'Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)', Journal of the National Cancer Institute, vol. 98, no. 5, pp. 345-354. https://doi.org/10.1093/jnci/djj071

TY - JOUR

T1 - Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

AU - Gonzalez, Carlos A

AU - Jakszyn, Paula

AU - Pera, Guillem

AU - Agudo, Antonio

AU - Bingham, Sheila

AU - Palli, Domenico

AU - Ferrari, Pietro

AU - Boeing, Heiner

AU - del Giudice, Giuseppe

AU - Plebani, Mario

AU - Carneiro, Fatima

AU - Nesi, Gabriella

AU - Berrino, Franco

AU - Sacerdote, Carlotta

AU - Tumino, R

AU - Panico, Salvatore

AU - Berglund, Göran

AU - Simán, Henrik

AU - Nyrén, Olof

AU - Martinez, Carmen

AU - Hallmans, Göran

AU - Dorronsoro,, Miren

AU - Barricarte, Aurelio

AU - Navarro, Carmen

AU - Quirós, José R.

AU - Allen, Naomi

AU - Key, Timothy J.

AU - Day, Nicholas E.

AU - Linseisen, Jakob

AU - Nagel, Gabriele

AU - Bergmann, Manuela M.

AU - Overvad, Kim

AU - ensen, Majken K. J

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Bueno-de-Mesquita, H. Bas

AU - Ocke, Marga

AU - Peeters, Petra H. M.

AU - Numans, Mattijs E.

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie-Christine

AU - Trichopoulou, Antonia

AU - Psaltopoulou, Theodora

AU - Roukos, Dimitrios

AU - Lund, Eiliv

AU - Hemon, Bertrand

AU - Kaaks, Rudolf

AU - Norat, Teresa

AU - Riboli, Elio

PY - 2006

Y1 - 2006

N2 - BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. METHODS: A total of 521,457 men and women aged 35-70 years in 10 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric non-cardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. RESULTS: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric non-cardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI = 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric non-cardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. CONCLUSION: Total, red, and processed meat intakes were associated with an increased risk of gastric non-cardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.

AB - BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. METHODS: A total of 521,457 men and women aged 35-70 years in 10 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric non-cardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. RESULTS: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric non-cardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI = 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric non-cardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. CONCLUSION: Total, red, and processed meat intakes were associated with an increased risk of gastric non-cardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer.

U2 - 10.1093/jnci/djj071

DO - 10.1093/jnci/djj071

M3 - Article

C2 - 16507831

SN - 1460-2105

VL - 98

SP - 345

EP - 354

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 5

ER -

Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Abstract

Subject classification (UKÄ)

UN SDGs

Access to Document

Fingerprint

Cite this