Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study

Catherine Dong; Simon S M Chan; Prevost Jantchou; Antoine Racine; Bas Oldenburg; Elisabete Weiderpass; Alicia K Heath; Tammy Y N Tong; Anne Tjønneland; Cecilie Kyrø; Bas Bueno de Mesquita; Rudolf Kaaks; Verena A Katzke; Manuela M Bergman; Heiner Boeing; Domenico Palli; Giovanna Masala; Rosario Tumino; Carlotta Sacerdote; Sandra M Colorado-Yohar; Maria-Jose Sánchez; Olof Grip; Stefan Lindgren; Robert Luben; Inge Huybrechts; Marc J Gunter; Yahya Mahamat-Saleh; Marie-Christine Boutron-Ruault; Franck Carbonnel

doi:10.1093/ecco-jcc/jjac054

Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study

Catherine Dong, Simon S M Chan, Prevost Jantchou, Antoine Racine, Bas Oldenburg, Elisabete Weiderpass, Alicia K Heath, Tammy Y N Tong, Anne Tjønneland, Cecilie Kyrø, Bas Bueno de Mesquita, Rudolf Kaaks, Verena A Katzke, Manuela M Bergman, Heiner Boeing, Domenico Palli, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Sandra M Colorado-YoharMaria-Jose Sánchez, Olof Grip, Stefan Lindgren, Robert Luben, Inge Huybrechts, Marc J Gunter, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Franck Carbonnel

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition.

METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors of measures related to each country-specific questionnaire. Associations between proteins (total, animal, and vegetable) or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.

RESULTS: After a mean follow-up of 16 years, 177 patients with Crohn's disease (CD) and 418 with ulcerative colitis (UC), were identified. There was no association between total protein, animal, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (HR for the 4 thvs. 1 st quartile = 1.40; 95% CI = 0.99-1.98; P-trend = 0.01; and 1.61; 95% CI = 1.10-2.36, P-trend = 0.007, respectively). There was no association between other food sources of animal protein (processed meat, fish, shellfish, eggs, poultry) and UC. We found no association between food sources of animal proteins and CD risk.

CONCLUSION: Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counseling of low meat intake in people at high-risk of IBD.

Original language	English
Pages (from-to)	1187-1196
Journal	Journal of Crohn's & Colitis
Volume	16
Issue number	8
Early online date	2022 Apr 9
DOIs	https://doi.org/10.1093/ecco-jcc/jjac054
Publication status	Published - 2022
Externally published	Yes

Bibliographical note

Subject classification (UKÄ)

Gastroenterology and Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ecco-jcc/jjac054

Cite this

Dong, C., Chan, S. S. M., Jantchou, P., Racine, A., Oldenburg, B., Weiderpass, E., Heath, A. K., Tong, T. Y. N., Tjønneland, A., Kyrø, C., de Mesquita, B. B., Kaaks, R., Katzke, V. A., Bergman, M. M., Boeing, H., Palli, D., Masala, G., Tumino, R., Sacerdote, C., ... Carbonnel, F. (2022). Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study. Journal of Crohn's & Colitis, 16(8), 1187-1196. https://doi.org/10.1093/ecco-jcc/jjac054

@article{f6edc9d68efa4fec80399e73534d45da,

title = "Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study",

abstract = "BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition.METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors of measures related to each country-specific questionnaire. Associations between proteins (total, animal, and vegetable) or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.RESULTS: After a mean follow-up of 16 years, 177 patients with Crohn's disease (CD) and 418 with ulcerative colitis (UC), were identified. There was no association between total protein, animal, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (HR for the 4 thvs. 1 st quartile = 1.40; 95% CI = 0.99-1.98; P-trend = 0.01; and 1.61; 95% CI = 1.10-2.36, P-trend = 0.007, respectively). There was no association between other food sources of animal protein (processed meat, fish, shellfish, eggs, poultry) and UC. We found no association between food sources of animal proteins and CD risk.CONCLUSION: Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counseling of low meat intake in people at high-risk of IBD.",

author = "Catherine Dong and Chan, {Simon S M} and Prevost Jantchou and Antoine Racine and Bas Oldenburg and Elisabete Weiderpass and Heath, {Alicia K} and Tong, {Tammy Y N} and Anne Tj{\o}nneland and Cecilie Kyr{\o} and {de Mesquita}, {Bas Bueno} and Rudolf Kaaks and Katzke, {Verena A} and Bergman, {Manuela M} and Heiner Boeing and Domenico Palli and Giovanna Masala and Rosario Tumino and Carlotta Sacerdote and Colorado-Yohar, {Sandra M} and Maria-Jose S{\'a}nchez and Olof Grip and Stefan Lindgren and Robert Luben and Inge Huybrechts and Gunter, {Marc J} and Yahya Mahamat-Saleh and Marie-Christine Boutron-Ruault and Franck Carbonnel",

note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of European Crohn{\textquoteright}s and Colitis Organisation. All rights reserved. For permissions, please email: [email protected].",

year = "2022",

doi = "10.1093/ecco-jcc/jjac054",

language = "English",

volume = "16",

pages = "1187--1196",

journal = "Journal of Crohn's & Colitis",

issn = "1873-9946",

publisher = "Oxford University Press",

number = "8",

}

Dong, C, Chan, SSM, Jantchou, P, Racine, A, Oldenburg, B, Weiderpass, E, Heath, AK, Tong, TYN, Tjønneland, A, Kyrø, C, de Mesquita, BB, Kaaks, R, Katzke, VA, Bergman, MM, Boeing, H, Palli, D, Masala, G, Tumino, R, Sacerdote, C, Colorado-Yohar, SM, Sánchez, M-J, Grip, O , Lindgren, S, Luben, R, Huybrechts, I, Gunter, MJ, Mahamat-Saleh, Y, Boutron-Ruault, M-C & Carbonnel, F 2022, 'Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study', Journal of Crohn's & Colitis, vol. 16, no. 8, pp. 1187-1196. https://doi.org/10.1093/ecco-jcc/jjac054

TY - JOUR

T1 - Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study

AU - Dong, Catherine

AU - Chan, Simon S M

AU - Jantchou, Prevost

AU - Racine, Antoine

AU - Oldenburg, Bas

AU - Weiderpass, Elisabete

AU - Heath, Alicia K

AU - Tong, Tammy Y N

AU - Tjønneland, Anne

AU - Kyrø, Cecilie

AU - de Mesquita, Bas Bueno

AU - Kaaks, Rudolf

AU - Katzke, Verena A

AU - Bergman, Manuela M

AU - Boeing, Heiner

AU - Palli, Domenico

AU - Masala, Giovanna

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Colorado-Yohar, Sandra M

AU - Sánchez, Maria-Jose

AU - Grip, Olof

AU - Lindgren, Stefan

AU - Luben, Robert

AU - Huybrechts, Inge

AU - Gunter, Marc J

AU - Mahamat-Saleh, Yahya

AU - Boutron-Ruault, Marie-Christine

AU - Carbonnel, Franck

PY - 2022

Y1 - 2022

N2 - BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition.METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors of measures related to each country-specific questionnaire. Associations between proteins (total, animal, and vegetable) or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.RESULTS: After a mean follow-up of 16 years, 177 patients with Crohn's disease (CD) and 418 with ulcerative colitis (UC), were identified. There was no association between total protein, animal, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (HR for the 4 thvs. 1 st quartile = 1.40; 95% CI = 0.99-1.98; P-trend = 0.01; and 1.61; 95% CI = 1.10-2.36, P-trend = 0.007, respectively). There was no association between other food sources of animal protein (processed meat, fish, shellfish, eggs, poultry) and UC. We found no association between food sources of animal proteins and CD risk.CONCLUSION: Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counseling of low meat intake in people at high-risk of IBD.

AB - BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition.METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors of measures related to each country-specific questionnaire. Associations between proteins (total, animal, and vegetable) or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.RESULTS: After a mean follow-up of 16 years, 177 patients with Crohn's disease (CD) and 418 with ulcerative colitis (UC), were identified. There was no association between total protein, animal, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (HR for the 4 thvs. 1 st quartile = 1.40; 95% CI = 0.99-1.98; P-trend = 0.01; and 1.61; 95% CI = 1.10-2.36, P-trend = 0.007, respectively). There was no association between other food sources of animal protein (processed meat, fish, shellfish, eggs, poultry) and UC. We found no association between food sources of animal proteins and CD risk.CONCLUSION: Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counseling of low meat intake in people at high-risk of IBD.

U2 - 10.1093/ecco-jcc/jjac054

DO - 10.1093/ecco-jcc/jjac054

M3 - Article

C2 - 35396592

SN - 1873-9946

VL - 16

SP - 1187

EP - 1196

JO - Journal of Crohn's & Colitis

JF - Journal of Crohn's & Colitis

IS - 8

ER -

Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study

Abstract

Bibliographical note

Subject classification (UKÄ)

UN SDGs

Access to Document

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Cite this