Mechanism of NADH transfer among dehydrogenases

Wilma Martinez Arias, Henrik Pettersson, Gösta Pettersson

Research output: Contribution to journalArticlepeer-review


Steady-state and transient-state kinetic experiments have been performed to test the proposal that there is a direct (channelled) transfer of NADH from one dehydrogenase to another if the two enzymes exhibit distinct chiral coenzyme specificity (A-side vs. B-side). The results lend no support to this proposal, but are fully consistent with a free-diffusion mechanism of NADH transfer irrespective of the chiral specificity of the enzymes.
Original languageEnglish
Pages (from-to)149-156
JournalBBA - Protein Structure and Molecular Enzymology
Issue number1
Publication statusPublished - 1998

Subject classification (UKÄ)

  • Basic Medicine

Free keywords

  • Dehydrogenase
  • Channelling
  • Enzyme kinetics


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