Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Esther Molina-Montes; María José Sánchez; Genevieve Buckland; H. B. Bueno-De-Mesquita; Elisabete Weiderpass; Pilar Amiano; Petra A. Wark; Tilman Kühn; Verena Katzke; José María Huerta; Eva Ardanaz; José Ramón Quirós; Aurélie Affret; Mathilde His; Marie Christine Boutron-Ruault; Petra H. Peeters; Weimin Ye; Malin Sund; Heiner Boeing; Khalid Iqbal; Bodil Ohlsson; Emily Sonestedt; Anne Tjønneland; Kristina E.N. Petersen; Ruth C. Travis; Guri Skeie; Claudia Agnoli; Salvatore Panico; Domenico Palli; Rosario Tumino; Carlotta Sacerdote; Heinz Freisling; Inge Huybrechts; Kim Overvad; Antonia Trichopoulou; Christina Bamia; Effie Vasilopoulou; Nick Wareham; Kay Tee Khaw; Amanda J. Cross; Heather A. Ward; Elio Riboli; Eric J. Duell

doi:10.1038/bjc.2017.14

Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Esther Molina-Montes, María José Sánchez, Genevieve Buckland, H. B. Bueno-De-Mesquita, Elisabete Weiderpass, Pilar Amiano, Petra A. Wark, Tilman Kühn, Verena Katzke, José María Huerta, Eva Ardanaz, José Ramón Quirós, Aurélie Affret, Mathilde His, Marie Christine Boutron-Ruault, Petra H. Peeters, Weimin Ye, Malin Sund, Heiner Boeing, Khalid IqbalBodil Ohlsson, Emily Sonestedt, Anne Tjønneland, Kristina E.N. Petersen, Ruth C. Travis, Guri Skeie, Claudia Agnoli, Salvatore Panico, Domenico Palli, Rosario Tumino, Carlotta Sacerdote, Heinz Freisling, Inge Huybrechts, Kim Overvad, Antonia Trichopoulou, Christina Bamia, Effie Vasilopoulou, Nick Wareham, Kay Tee Khaw, Amanda J. Cross, Heather A. Ward, Elio Riboli, Eric J. Duell

Research output: Contribution to journal › Article › peer-review

Abstract

Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

Original language	English
Pages (from-to)	811-820
Number of pages	10
Journal	British Journal of Cancer
Volume	116
Issue number	6
DOIs	https://doi.org/10.1038/bjc.2017.14
Publication status	Published - 2017 Mar 14

Subject classification (UKÄ)

Cancer and Oncology
Nutrition and Dietetics

Free keywords

cohort study
Mediterranean diet
pancreatic cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Molina-Montes, E., Sánchez, M. J., Buckland, G., Bueno-De-Mesquita, H. B., Weiderpass, E., Amiano, P., Wark, P. A., Kühn, T., Katzke, V., Huerta, J. M., Ardanaz, E., Quirós, J. R., Affret, A., His, M., Boutron-Ruault, M. C., Peeters, P. H., Ye, W., Sund, M., Boeing, H., ... Duell, E. J. (2017). Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. British Journal of Cancer, 116(6), 811-820. https://doi.org/10.1038/bjc.2017.14

@article{0a5c1af03c134a85be94097bd0d7c26a,

title = "Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort",

abstract = "Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.",

keywords = "cohort study, Mediterranean diet, pancreatic cancer",

author = "Esther Molina-Montes and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Genevieve Buckland and Bueno-De-Mesquita, {H. B.} and Elisabete Weiderpass and Pilar Amiano and Wark, {Petra A.} and Tilman K{\"u}hn and Verena Katzke and Huerta, {Jos{\'e} Mar{\'i}a} and Eva Ardanaz and Quir{\'o}s, {Jos{\'e} Ram{\'o}n} and Aur{\'e}lie Affret and Mathilde His and Boutron-Ruault, {Marie Christine} and Peeters, {Petra H.} and Weimin Ye and Malin Sund and Heiner Boeing and Khalid Iqbal and Bodil Ohlsson and Emily Sonestedt and Anne Tj{\o}nneland and Petersen, {Kristina E.N.} and Travis, {Ruth C.} and Guri Skeie and Claudia Agnoli and Salvatore Panico and Domenico Palli and Rosario Tumino and Carlotta Sacerdote and Heinz Freisling and Inge Huybrechts and Kim Overvad and Antonia Trichopoulou and Christina Bamia and Effie Vasilopoulou and Nick Wareham and Khaw, {Kay Tee} and Cross, {Amanda J.} and Ward, {Heather A.} and Elio Riboli and Duell, {Eric J.}",

year = "2017",

month = mar,

day = "14",

doi = "10.1038/bjc.2017.14",

language = "English",

volume = "116",

pages = "811--820",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "6",

}

Molina-Montes, E, Sánchez, MJ, Buckland, G, Bueno-De-Mesquita, HB, Weiderpass, E, Amiano, P, Wark, PA, Kühn, T, Katzke, V, Huerta, JM, Ardanaz, E, Quirós, JR, Affret, A, His, M, Boutron-Ruault, MC, Peeters, PH, Ye, W, Sund, M, Boeing, H, Iqbal, K, Ohlsson, B , Sonestedt, E, Tjønneland, A, Petersen, KEN, Travis, RC, Skeie, G, Agnoli, C, Panico, S, Palli, D, Tumino, R, Sacerdote, C, Freisling, H, Huybrechts, I, Overvad, K, Trichopoulou, A, Bamia, C, Vasilopoulou, E, Wareham, N, Khaw, KT, Cross, AJ, Ward, HA, Riboli, E & Duell, EJ 2017, 'Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort', British Journal of Cancer, vol. 116, no. 6, pp. 811-820. https://doi.org/10.1038/bjc.2017.14

TY - JOUR

T1 - Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

AU - Molina-Montes, Esther

AU - Sánchez, María José

AU - Buckland, Genevieve

AU - Bueno-De-Mesquita, H. B.

AU - Weiderpass, Elisabete

AU - Amiano, Pilar

AU - Wark, Petra A.

AU - Kühn, Tilman

AU - Katzke, Verena

AU - Huerta, José María

AU - Ardanaz, Eva

AU - Quirós, José Ramón

AU - Affret, Aurélie

AU - His, Mathilde

AU - Boutron-Ruault, Marie Christine

AU - Peeters, Petra H.

AU - Ye, Weimin

AU - Sund, Malin

AU - Boeing, Heiner

AU - Iqbal, Khalid

AU - Ohlsson, Bodil

AU - Sonestedt, Emily

AU - Tjønneland, Anne

AU - Petersen, Kristina E.N.

AU - Travis, Ruth C.

AU - Skeie, Guri

AU - Agnoli, Claudia

AU - Panico, Salvatore

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Freisling, Heinz

AU - Huybrechts, Inge

AU - Overvad, Kim

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Vasilopoulou, Effie

AU - Wareham, Nick

AU - Khaw, Kay Tee

AU - Cross, Amanda J.

AU - Ward, Heather A.

AU - Riboli, Elio

AU - Duell, Eric J.

PY - 2017/3/14

Y1 - 2017/3/14

N2 - Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

AB - Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

KW - cohort study

KW - Mediterranean diet

KW - pancreatic cancer

UR - http://www.scopus.com/inward/record.url?scp=85011915417&partnerID=8YFLogxK

U2 - 10.1038/bjc.2017.14

DO - 10.1038/bjc.2017.14

M3 - Article

C2 - 28170373

AN - SCOPUS:85011915417

SN - 0007-0920

VL - 116

SP - 811

EP - 820

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 6

ER -

Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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