We demonstrate direct visualization of melting mapping of DNA stretched in nanoscale channels using standard staining methods and epifluorescence microscopy to gain information on the local AT/GC ratio along large DNA molecules. Our development opens up a novel route to mapping of large-scale genomic variations.
|Number of pages||3|
|Publication status||Published - 2008 Jan 1|
|Event||12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States|
Duration: 2008 Oct 12 → 2008 Oct 16
|Conference||12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008|
|City||San Diego, CA|
|Period||2008/10/12 → 2008/10/16|