Melting mapping in nanochannels

Walter W. Reisner, Henrik Flyvbjerg, Jonas O. Tegenfeldt

Research output: Contribution to conferencePaper, not in proceedingpeer-review

Abstract

We demonstrate direct visualization of melting mapping of DNA stretched in nanoscale channels[1] using standard staining methods and epifluorescence microscopy to gain information on the local AT/GC ratio along large DNA molecules. Our development opens up a novel route to mapping of large-scale genomic variations.

Original languageEnglish
Pages1516-1518
Number of pages3
Publication statusPublished - 2008 Jan 1
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: 2008 Oct 122008 Oct 16

Conference

Conference12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/TerritoryUnited States
CitySan Diego, CA
Period2008/10/122008/10/16

Free keywords

  • DNA
  • Genomics
  • Melting
  • Nanofluidics

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