Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.

Ulrika Axling; Liza Rosén; Elin Östman; Kristoffer Ström; Nils Wierup; Inger Björck; Cecilia Holm

doi:10.1016/j.nut.2009.06.007

Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.

Ulrika Axling, Liza Rosén, Elin Östman, Kristoffer Ström, Nils Wierup, Inger Björck, Cecilia Holm

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: A diet rich in whole grain cereals is suggested to protect against type 2 diabetes and facilitate body weight regulation. However, little is known about the impact of different cereals and the underlying mechanisms. The objective of this study was to compare the long-term metabolic effects of diets supplemented with whole grain wheat or whole grain rye in the C57BL/6J mouse. METHODS: Mice were fed the whole grain supplements in a low-fat background diet for 22 wk. Oral and intravenous glucose tolerance tests were performed during the study and in vitro insulin secretion assays were performed at the end of the study. Body weight, energy intake, body fat content, and plasma parameters were measured during the study. RESULTS: A dietary supplement of whole grain rye suppressed body weight gain and resulted in significantly decreased adiposity, plasma leptin, total plasma cholesterol, and triacylglycerols compared with a supplement of whole grain wheat. Also, a slight improvement in insulin sensitivity was observed in the rye group compared with the wheat group. The decreases in body weight and adiposity were observed in the absence of differences in energy intake. CONCLUSION: Long-term administration of whole grain rye evokes a different metabolic profile compared with whole grain wheat in the C57BL/6J mouse, the primary difference being that whole grain rye reduces body weight and adiposity compared with whole grain wheat. In addition, whole grain rye slightly improves insulin sensitivity and lowers total plasma cholesterol.

Original language	English
Pages (from-to)	230-239
Journal	Nutrition
Volume	26
DOIs	https://doi.org/10.1016/j.nut.2009.06.007
Publication status	Published - 2010

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Molecular Endocrinology (013212018), Neuroendocrine Cell Biology (013212008), Applied Nutrition and Food Chemistry (011001300)

Subject classification (UKÄ)

Endocrinology and Diabetes
Cell and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.nut.2009.06.007

http://www.ncbi.nlm.nih.gov/pubmed/19647415?dopt=Abstract

1 Doctoral Thesis (compilation)

Exploring food concepts for the prevention of type 2 diabetes
Axling, U., 2011, Department of Experimental Medical Science, Lund Univeristy. 156 p.
Research output: Thesis › Doctoral Thesis (compilation)

1 Finished

AFC: ANTIDIABETIC FOOD CENTRE
Adlercreutz, P. (PI), Ahrén, I. L. (PI), Ahrné, S. (Researcher), Alhamimi, S. (Research student), Andersson, K. E. (Researcher), Andersson, K. E. (Research student), Månberger, A. (Researcher), Axling, U. (Researcher), Axling, U. (Research student), Bergenståhl, B. (Researcher), Berger, K. (PI), Björck, I. (PI), Bränning, C. (Research student), Bäckhed, F. (PI), Zanzer, Y. C. (Research student), Danielsson, A. (PI), Danielsson, B. (Research assistant), Degerman, E. (PI), Dejmek, P. (Researcher), Dey, E. (PI), Dougkas, A. (Researcher), Ekström, L. (Research student), Eliasson, A.-C. (PI), Fahlgren, C. (Research engineer), Falck, P. (PI), Falck, P. (Research student), Ghaffarzadegan, T. (Research student), Granfeldt, Y. (Researcher), Grey, C. (Researcher), Gunnerud, U. (Research student), Håkansson, Å. (Researcher), Håkansson, Å. (Research student), Hållenius, F. (Researcher), Hållenius, F. (PI), Haskå, L. (PI), Haskå, L. (Research student), Heimann, E. (Research student), Hellstrand, P. (Researcher), Heyman, L. (Research student), Holm Wallenberg, C. (PI), Holmén-Pålbrink, A.-K. (Research assistant), Holst, O. (Researcher), Immerstrand, T. (Research student), Immerzeel, P. (Researcher), Jakobsdottir, G. (Research student), Jeppsson, B. (Researcher), Johansson, E. (Research student), Johansson, M. (Project coordinator), Johansson, M. (Researcher), Johansson, M. (Research assistant), Johansson, U. (Researcher), Jones, H. (Researcher), Nordberg Karlsson, E. (Researcher), Kovatcheva-Datchary, P. (Researcher), Kulcinskaja, E. (Research student), Landin-Olsson, M. (Researcher), Linninge, C. (Researcher), Marefati, A. (Research student), Marungruang, N. (Research student), Molin, G. (PI), Nilsson, A. (PI), Nilsson, E. (Research engineer), Nilsson, U. (PI), Nyman, M. (PI), Ohlson, E. (Research assistant), Olsson, C. (Researcher), Öste, R. (PI), Östman, E. (PI), Persson, L. (Research engineer), Persson, S. (Researcher), Plaza, M. (Researcher), Prykhodko, O. (Researcher), Radeborg, K. (Researcher), Rayner, M. (PI), Rosén, L. (Research student), Sandahl, M. (Researcher), Sandberg, J. (Research student), Sjöö, M. (PI), Skog, K. (Researcher), Spégel, P. (PI), Stålbrand, H. (Researcher), Sterner, O. (PI), Svensson, J. (Research student), Tareke, E. (PI), Tovar, J. (PI), Turner, C. (PI), Weström, B. (Researcher), Xu, J. (Research student) & Zhong, Y. (Research student)
2007/07/01 → 2018/01/31
Project: Research

Cite this

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title = "Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.",

abstract = "OBJECTIVE: A diet rich in whole grain cereals is suggested to protect against type 2 diabetes and facilitate body weight regulation. However, little is known about the impact of different cereals and the underlying mechanisms. The objective of this study was to compare the long-term metabolic effects of diets supplemented with whole grain wheat or whole grain rye in the C57BL/6J mouse. METHODS: Mice were fed the whole grain supplements in a low-fat background diet for 22 wk. Oral and intravenous glucose tolerance tests were performed during the study and in vitro insulin secretion assays were performed at the end of the study. Body weight, energy intake, body fat content, and plasma parameters were measured during the study. RESULTS: A dietary supplement of whole grain rye suppressed body weight gain and resulted in significantly decreased adiposity, plasma leptin, total plasma cholesterol, and triacylglycerols compared with a supplement of whole grain wheat. Also, a slight improvement in insulin sensitivity was observed in the rye group compared with the wheat group. The decreases in body weight and adiposity were observed in the absence of differences in energy intake. CONCLUSION: Long-term administration of whole grain rye evokes a different metabolic profile compared with whole grain wheat in the C57BL/6J mouse, the primary difference being that whole grain rye reduces body weight and adiposity compared with whole grain wheat. In addition, whole grain rye slightly improves insulin sensitivity and lowers total plasma cholesterol.",

author = "Ulrika Axling and Liza Ros{\'e}n and Elin {\"O}stman and Kristoffer Str{\"o}m and Nils Wierup and Inger Bj{\"o}rck and Cecilia Holm",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Endocrinology (013212018), Neuroendocrine Cell Biology (013212008), Applied Nutrition and Food Chemistry (011001300)",

year = "2010",

doi = "10.1016/j.nut.2009.06.007",

language = "English",

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pages = "230--239",

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T1 - Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.

AU - Axling, Ulrika

AU - Rosén, Liza

AU - Östman, Elin

AU - Ström, Kristoffer

AU - Wierup, Nils

AU - Björck, Inger

AU - Holm, Cecilia

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Endocrinology (013212018), Neuroendocrine Cell Biology (013212008), Applied Nutrition and Food Chemistry (011001300)

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: A diet rich in whole grain cereals is suggested to protect against type 2 diabetes and facilitate body weight regulation. However, little is known about the impact of different cereals and the underlying mechanisms. The objective of this study was to compare the long-term metabolic effects of diets supplemented with whole grain wheat or whole grain rye in the C57BL/6J mouse. METHODS: Mice were fed the whole grain supplements in a low-fat background diet for 22 wk. Oral and intravenous glucose tolerance tests were performed during the study and in vitro insulin secretion assays were performed at the end of the study. Body weight, energy intake, body fat content, and plasma parameters were measured during the study. RESULTS: A dietary supplement of whole grain rye suppressed body weight gain and resulted in significantly decreased adiposity, plasma leptin, total plasma cholesterol, and triacylglycerols compared with a supplement of whole grain wheat. Also, a slight improvement in insulin sensitivity was observed in the rye group compared with the wheat group. The decreases in body weight and adiposity were observed in the absence of differences in energy intake. CONCLUSION: Long-term administration of whole grain rye evokes a different metabolic profile compared with whole grain wheat in the C57BL/6J mouse, the primary difference being that whole grain rye reduces body weight and adiposity compared with whole grain wheat. In addition, whole grain rye slightly improves insulin sensitivity and lowers total plasma cholesterol.

AB - OBJECTIVE: A diet rich in whole grain cereals is suggested to protect against type 2 diabetes and facilitate body weight regulation. However, little is known about the impact of different cereals and the underlying mechanisms. The objective of this study was to compare the long-term metabolic effects of diets supplemented with whole grain wheat or whole grain rye in the C57BL/6J mouse. METHODS: Mice were fed the whole grain supplements in a low-fat background diet for 22 wk. Oral and intravenous glucose tolerance tests were performed during the study and in vitro insulin secretion assays were performed at the end of the study. Body weight, energy intake, body fat content, and plasma parameters were measured during the study. RESULTS: A dietary supplement of whole grain rye suppressed body weight gain and resulted in significantly decreased adiposity, plasma leptin, total plasma cholesterol, and triacylglycerols compared with a supplement of whole grain wheat. Also, a slight improvement in insulin sensitivity was observed in the rye group compared with the wheat group. The decreases in body weight and adiposity were observed in the absence of differences in energy intake. CONCLUSION: Long-term administration of whole grain rye evokes a different metabolic profile compared with whole grain wheat in the C57BL/6J mouse, the primary difference being that whole grain rye reduces body weight and adiposity compared with whole grain wheat. In addition, whole grain rye slightly improves insulin sensitivity and lowers total plasma cholesterol.

U2 - 10.1016/j.nut.2009.06.007

DO - 10.1016/j.nut.2009.06.007

M3 - Article

SN - 1873-1244

VL - 26

SP - 230

EP - 239

JO - Nutrition

JF - Nutrition

ER -

Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.

Abstract

Bibliographical note

Subject classification (UKÄ)

UN SDGs

Access to Document

Fingerprint

Research output

Exploring food concepts for the prevention of type 2 diabetes

Projects

AFC: ANTIDIABETIC FOOD CENTRE

Cite this