Projects per year
The objective of the present thesis was to investigate the impact of whey and soy protein on postprandial blood glucose, plasma AA (p-AA) and hormonal responses when administered to healthy subjects in a glucose drink, as part of milk meals, or in combination with a composite carbohydrate meal. The effect of exchanging half of the protein for specific AA mixtures (5AA: isoleucine, leucine, lysine, threonine and valine) or (6AA: 5AA+arginine) was also examined. Additionally appetite rating in the postprandial phase was performed using VAS scales.
Whey protein (4.5-18g) reduced postprandial glycaemia, and increased insulinaemia and p-AA in a dose dependent way to a glucose challenge, and the p-5AA (iAUC 0-60 min) correlated to the insulin response (iPeak; P < 0.009). Lactose-equivalent amounts of bovine and human milk resulted in similar postprandial glycaemia and insulinaemia. A rapid response in GIP, GLP-1 and p-AA correlated to an early insulinogenic effect that was associated to reduction of glycaemia (iAUC 0-90 min; P < 0.001). Hydrolysed and intact whey had similar effects on glycaemic responses when co-ingested with glucose, although hydrolysed way tended to be more insulinogenic, possible due to its higher early insulin and faster p-AA response compared with intact whey. Exchanging half of the intact or hydrolysed whey protein for 5AA magnified the insulinogenic effect and reduced postprandial glycaemia (iAUC 0-120min; P < 0.05).
Intake of whey or soy protein with or without addition of 5AA or 6AA, as a pre-meal protein drink (PMPD) prior a composite meal, considerably attenuated postprandial blood glucose incremental peak value (iPeak; P < 0.05). Also, all whey PMPDs with or without added AA reduced glycaemia (iAUC 0-120min; P < 0.05) and increased the Glycaemic Profile (GP; P < 0.05). Arginine had no additional effect on glycaemic responses when added to the 5AA mixture. Early GLP-1 and p-AA responses (iAUC 0-15 min) were associated with early insulin response (iAUC 0-15min). Early increment in insulin possibly explain the attenuation of over-all course of post-prandial glycaemia to the composite carbohydrate meal post the PMPDs. Interestingly, the lowering of glycaemic excursions was observed in the absence of elevated insulinaemic peak. Intake of a PMPD prior a composite meal had no effects on appetite rating (VAS) or plasma ghrelin.
|Award date||2013 Mar 22|
|Publication status||Published - 2013|
Bibliographical noteDefence details
Place: Lecture Hall B, Chemical Centre, Getingevägen 60, Lund University, Faculty of Engineering
Name: Gannon, Mary
Affiliation: Departments of Medicine and Food Science and Nutrition, University of Minnesota, Minneapolis, USA
The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300)
Subject classification (UKÄ)
- Nutrition and Dietetics
- Amino acids
- dietary protein
- glycaemic regulation
FingerprintDive into the research topics of 'Metabolic impact of certain dietary proteins and/or amino acids - Glycaemic and hormonal responses to carbohydrate meals in healthy subject'. Together they form a unique fingerprint.
- 1 Finished
Adlercreutz, P., Ahrén, I. L., Ahrné, S., Alhamimi, S., Andersson, K. E., Andersson, K. E., Månberger, A., Axling, U., Axling, U., Bergenståhl, B., Berger, K., Björck, I., Bränning, C., Bäckhed, F., Zanzer, Y. C., Danielsson, A., Danielsson, B., Degerman, E., Dejmek, P., Dey, E., Dougkas, A., Ekström, L., Eliasson, A., Fahlgren, C., Falck, P., Falck, P., Ghaffarzadegan, T., Granfeldt, Y., Grey, C., Gunnerud, U., Håkansson, Å., Håkansson, Å., Hållenius, F., Hållenius, F., Haskå, L., Haskå, L., Heimann, E., Hellstrand, P., Heyman, L., Holm Wallenberg, C., Holmén-Pålbrink, A., Holst, O., Immerstrand, T., Immerzeel, P., Jakobsdottir, G., Jeppsson, B., Johansson, E., Johansson, M., Johansson, M., Johansson, M., Johansson, U., Jones, H., Nordberg Karlsson, E., Kovatcheva-Datchary, P., Kulcinskaja, E., Landin-Olsson, M., Linninge, C., Marefati, A., Marungruang, N., Molin, G., Nilsson, A., Nilsson, E., Nilsson, U., Nyman, M., Ohlson, E., Olsson, C., Öste, R., Östman, E., Persson, L., Persson, S., Plaza, M., Prykhodko, O., Radeborg, K., Rayner, M., Rosén, L., Sandahl, M., Sandberg, J., Sjöö, M., Skog, K., Spégel, P., Stålbrand, H., Sterner, O., Svensson, J., Tareke, E., Tovar, J., Turner, C., Weström, B., Xu, J. & Zhong, Y.
2007/07/01 → 2018/01/31