Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults

Wegene Borena; Susanne Strohmaier; Annekatrin Lukanova; Tone Bjorge; Bjorn Lindkvist; Goran Hallmans; Michael Edlinger; Tanja Stocks; Gabriele Nagel; Jonas Manjer; Anders Engeland; Randi Selmer; Christel Haggstrom; Steinar Tretli; Hans Concin; Hakan Jonsson; Par Stattin; Hanno Ulmer

doi:10.1002/ijc.26338

Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults

Wegene Borena, Susanne Strohmaier, Annekatrin Lukanova, Tone Bjorge, Bjorn Lindkvist, Goran Hallmans, Michael Edlinger, Tanja Stocks, Gabriele Nagel, Jonas Manjer, Anders Engeland, Randi Selmer, Christel Haggstrom, Steinar Tretli, Hans Concin, Hakan Jonsson, Par Stattin, Hanno Ulmer

Umeå University

Research output: Contribution to journal › Article › peer-review

Abstract

Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic risk factors and primary liver cancer (PLC) has not been investigated. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria and Sweden with data on 578,700 subjects. We used Cox proportional hazard models to calculate relative risks (RRs) of PLC by body mass index (BMI), blood pressure and plasma levels of glucose, cholesterol and triglycerides as continuous standardized variables (z-score with mean = 0 and standard deviation (SD) = 1) and their standardized sum of metabolic syndrome (MetS) z-score. RRs were corrected for random error in measurements. During an average follow-up of 12.0 years (SD = 7.8), 266 PLCs were diagnosed among cohort members. RR of liver cancer per unit increment of z-score adjusted for age, smoking status and BMI and stratified by birth year, sex and sub-cohorts, was for BMI 1.39 (95% confidence interval (CI) 1.241.58), mid blood pressure 2.08 (0.954.73), blood glucose 2.13 (1.552.94) cholesterol 0.62 (0.510.76) and serum triglycerides 0.85 (0.651.10). The RR per one unit increment of the MetS z-score was 1.35 (1.121.61). BMI, glucose and a composite MetS score were positively and cholesterol negatively associated with risk of liver cancer.

Original language	English
Pages (from-to)	193-200
Journal	International Journal of Cancer
Volume	131
Issue number	1
DOIs	https://doi.org/10.1002/ijc.26338
Publication status	Published - 2012

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

cohort study
epidemiology
hepatocellular carcinoma
intrahepatic
cholangiocarcinoma
metabolic syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.26338

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Borena, W., Strohmaier, S., Lukanova, A., Bjorge, T., Lindkvist, B., Hallmans, G., Edlinger, M., Stocks, T., Nagel, G., Manjer, J., Engeland, A., Selmer, R., Haggstrom, C., Tretli, S., Concin, H., Jonsson, H., Stattin, P., & Ulmer, H. (2012). Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults. International Journal of Cancer, 131(1), 193-200. https://doi.org/10.1002/ijc.26338

@article{d178fdebdac24ff2808a4d2d94aef4f3,

title = "Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults",

abstract = "Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic risk factors and primary liver cancer (PLC) has not been investigated. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria and Sweden with data on 578,700 subjects. We used Cox proportional hazard models to calculate relative risks (RRs) of PLC by body mass index (BMI), blood pressure and plasma levels of glucose, cholesterol and triglycerides as continuous standardized variables (z-score with mean = 0 and standard deviation (SD) = 1) and their standardized sum of metabolic syndrome (MetS) z-score. RRs were corrected for random error in measurements. During an average follow-up of 12.0 years (SD = 7.8), 266 PLCs were diagnosed among cohort members. RR of liver cancer per unit increment of z-score adjusted for age, smoking status and BMI and stratified by birth year, sex and sub-cohorts, was for BMI 1.39 (95% confidence interval (CI) 1.241.58), mid blood pressure 2.08 (0.954.73), blood glucose 2.13 (1.552.94) cholesterol 0.62 (0.510.76) and serum triglycerides 0.85 (0.651.10). The RR per one unit increment of the MetS z-score was 1.35 (1.121.61). BMI, glucose and a composite MetS score were positively and cholesterol negatively associated with risk of liver cancer.",

keywords = "cohort study, epidemiology, hepatocellular carcinoma, intrahepatic, cholangiocarcinoma, metabolic syndrome",

author = "Wegene Borena and Susanne Strohmaier and Annekatrin Lukanova and Tone Bjorge and Bjorn Lindkvist and Goran Hallmans and Michael Edlinger and Tanja Stocks and Gabriele Nagel and Jonas Manjer and Anders Engeland and Randi Selmer and Christel Haggstrom and Steinar Tretli and Hans Concin and Hakan Jonsson and Par Stattin and Hanno Ulmer",

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doi = "10.1002/ijc.26338",

language = "English",

volume = "131",

pages = "193--200",

journal = "International Journal of Cancer",

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Borena, W, Strohmaier, S, Lukanova, A, Bjorge, T, Lindkvist, B, Hallmans, G, Edlinger, M, Stocks, T, Nagel, G, Manjer, J, Engeland, A, Selmer, R, Haggstrom, C, Tretli, S, Concin, H, Jonsson, H, Stattin, P & Ulmer, H 2012, 'Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults', International Journal of Cancer, vol. 131, no. 1, pp. 193-200. https://doi.org/10.1002/ijc.26338

TY - JOUR

T1 - Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults

AU - Borena, Wegene

AU - Strohmaier, Susanne

AU - Lukanova, Annekatrin

AU - Bjorge, Tone

AU - Lindkvist, Bjorn

AU - Hallmans, Goran

AU - Edlinger, Michael

AU - Stocks, Tanja

AU - Nagel, Gabriele

AU - Manjer, Jonas

AU - Engeland, Anders

AU - Selmer, Randi

AU - Haggstrom, Christel

AU - Tretli, Steinar

AU - Concin, Hans

AU - Jonsson, Hakan

AU - Stattin, Par

AU - Ulmer, Hanno

PY - 2012

Y1 - 2012

N2 - Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic risk factors and primary liver cancer (PLC) has not been investigated. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria and Sweden with data on 578,700 subjects. We used Cox proportional hazard models to calculate relative risks (RRs) of PLC by body mass index (BMI), blood pressure and plasma levels of glucose, cholesterol and triglycerides as continuous standardized variables (z-score with mean = 0 and standard deviation (SD) = 1) and their standardized sum of metabolic syndrome (MetS) z-score. RRs were corrected for random error in measurements. During an average follow-up of 12.0 years (SD = 7.8), 266 PLCs were diagnosed among cohort members. RR of liver cancer per unit increment of z-score adjusted for age, smoking status and BMI and stratified by birth year, sex and sub-cohorts, was for BMI 1.39 (95% confidence interval (CI) 1.241.58), mid blood pressure 2.08 (0.954.73), blood glucose 2.13 (1.552.94) cholesterol 0.62 (0.510.76) and serum triglycerides 0.85 (0.651.10). The RR per one unit increment of the MetS z-score was 1.35 (1.121.61). BMI, glucose and a composite MetS score were positively and cholesterol negatively associated with risk of liver cancer.

AB - Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic risk factors and primary liver cancer (PLC) has not been investigated. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria and Sweden with data on 578,700 subjects. We used Cox proportional hazard models to calculate relative risks (RRs) of PLC by body mass index (BMI), blood pressure and plasma levels of glucose, cholesterol and triglycerides as continuous standardized variables (z-score with mean = 0 and standard deviation (SD) = 1) and their standardized sum of metabolic syndrome (MetS) z-score. RRs were corrected for random error in measurements. During an average follow-up of 12.0 years (SD = 7.8), 266 PLCs were diagnosed among cohort members. RR of liver cancer per unit increment of z-score adjusted for age, smoking status and BMI and stratified by birth year, sex and sub-cohorts, was for BMI 1.39 (95% confidence interval (CI) 1.241.58), mid blood pressure 2.08 (0.954.73), blood glucose 2.13 (1.552.94) cholesterol 0.62 (0.510.76) and serum triglycerides 0.85 (0.651.10). The RR per one unit increment of the MetS z-score was 1.35 (1.121.61). BMI, glucose and a composite MetS score were positively and cholesterol negatively associated with risk of liver cancer.

KW - cohort study

KW - epidemiology

KW - hepatocellular carcinoma

KW - intrahepatic

KW - cholangiocarcinoma

KW - metabolic syndrome

U2 - 10.1002/ijc.26338

DO - 10.1002/ijc.26338

M3 - Article

C2 - 21805476

SN - 0020-7136

VL - 131

SP - 193

EP - 200

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 1

ER -

Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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