Metabolic syndrome and rare gynecological cancers in the Metabolic syndrome and Cancer project (Me-Can)

G. Nagel, H. Concin, T. Bjorge, K. Rapp, Jonas Manjer, G. Hallmans, G. Diem, C. Haggstrom, A. Engeland, Martin Almquist, H. Jonsson, R. Selmer, T. Stocks, S. Tretli, H. Ulmer, P. Stattin, A. Lukanova

Research output: Contribution to journalArticlepeer-review

12 Citations (SciVal)

Abstract

Background: Risk factors for rare gynecological cancers are largely unknown. Initial research has indicated that the metabolic syndrome (MetS) or individual components could play a role. Materials and methods: The Metabolic syndrome and Cancer project cohort includes 288 834 women. During an average follow-up of 11 years, 82 vulvar, 26 vaginal and 43 other rare gynecological cancers were identified. Hazard ratios (HRs) were estimated fitting Cox proportional hazards regression models for tertiles and standardized z-scores [with a mean of 0 and a standard deviation (SD) of 1] of body mass index (BMI), blood pressure, glucose, cholesterol, triglycerides and MetS. Risk estimates were corrected for random error in the measurement of metabolic factors. Results: The MetS was associated with increased risk of vulvar [HR 1.78, 95% confidence interval (CI) 1.30-2.41) and vaginal cancer (HR 1.87, 95% CI 1.07-3.25). Among separate MetS components, 1 SD increase in BMI was associated with overall risk (HR 1.43, 95% CI 1.23-1.66), vulvar (HR 1.36, 95% CI 1.11-1.69) and vaginal cancer (HR 1.79, 95% CI 1.30-2.46). Blood glucose and triglyceride concentrations were associated with increased risk of vulvar cancer (HR 1.98, 95% CI 1.10-3.58 and HR 2.09, 95% CI 1.39-3.15, respectively). Conclusion: The results from this first prospective study on rare gynecological cancers suggest that the MetS and its individual components may play a role in the development of these tumors.
Original languageEnglish
Pages (from-to)1339-1345
JournalAnnals of Oncology
Volume22
Issue number6
DOIs
Publication statusPublished - 2011

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Surgery Research Unit (013242220)

Subject classification (UKÄ)

  • Cancer and Oncology

Keywords

  • epidemiology
  • MetS
  • rare gynecological cancers

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