Metabolite profiling of obese individuals before and after a one year weight loss program

N. Geidenstam; M. Al-Majdoub; M. Ekman; P. Spégel; M. Ridderstråle

doi:10.1038/ijo.2017.124

Metabolite profiling of obese individuals before and after a one year weight loss program

N. Geidenstam, M. Al-Majdoub, M. Ekman, P. Spégel, M. Ridderstråle

Research output: Contribution to journal › Article › peer-review

Abstract

Objective:We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.Methods:Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a 1 year non-surgical weight loss program.ResultsA total of 137 metabolites were identified and semi-quantified at baseline (BMI 42.7±5.8, mean±s.d.) and at follow-up (BMI 36.3±6.6). Weight-loss-induced modification was observed for levels of 57 metabolites in individuals with â

Original language	English
Pages (from-to)	1369-1378
Number of pages	10
Journal	International Journal of Obesity
Volume	41
Issue number	9
DOIs	https://doi.org/10.1038/ijo.2017.124
Publication status	Published - 2017 Sept 1

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Nutrition and Dietetics

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10.1038/ijo.2017.124

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AU - Geidenstam, N.

AU - Al-Majdoub, M.

AU - Ekman, M.

AU - Spégel, P.

AU - Ridderstråle, M.

PY - 2017/9/1

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N2 - Objective:We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.Methods:Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a 1 year non-surgical weight loss program.ResultsA total of 137 metabolites were identified and semi-quantified at baseline (BMI 42.7±5.8, mean±s.d.) and at follow-up (BMI 36.3±6.6). Weight-loss-induced modification was observed for levels of 57 metabolites in individuals with â

AB - Objective:We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.Methods:Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a 1 year non-surgical weight loss program.ResultsA total of 137 metabolites were identified and semi-quantified at baseline (BMI 42.7±5.8, mean±s.d.) and at follow-up (BMI 36.3±6.6). Weight-loss-induced modification was observed for levels of 57 metabolites in individuals with â

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Metabolite profiling of obese individuals before and after a one year weight loss program

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