Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

Theeraphon Piacham, C Isarankura-Na-Ayuldhya, C Nantasenamat, S Yainoy, Lei Ye, Leif Bülow, V Prachayasittikul

Research output: Contribution to journalArticlepeer-review

36 Citations (SciVal)

Abstract

Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)925-930
JournalBiochemical and Biophysical Research Communications
Volume341
Issue number4
DOIs
Publication statusPublished - 2006

Subject classification (UKÄ)

  • Biological Sciences

Keywords

  • molecular
  • modeling
  • SOD mimic
  • SOD
  • superoxide dismutase
  • antibiotic
  • bacitracin

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