Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.

Sarah Piel; Johannes Ehinger; Eskil Elmer; Magnus Hansson

doi:10.1111/apha.12311

Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.

Sarah Piel, Johannes Ehinger, Eskil Elmer, Magnus Hansson

Research output: Contribution to journal › Article › peer-review

Abstract

Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.

Original language	English
Pages (from-to)	171-180
Journal	Acta Physiologica
Volume	213
Issue number	1
DOIs	https://doi.org/10.1111/apha.12311
Publication status	Published - 2015

Subject classification (UKÄ)

Physiology

Access to Document

10.1111/apha.12311

http://www.ncbi.nlm.nih.gov/pubmed/24801139?dopt=Abstract

1 Article
1 Doctoral Thesis (compilation)

Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production
Piel, S., Ehinger, J. K., Chamkha, I., Frostner, E. Å., Sjövall, F., Elmér, E. & Hansson, M. J., 2018 Aug 1, In: Intensive Care Medicine Experimental. 6, 1, 22.
Research output: Contribution to journal › Article › peer-review

Open Access
Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse.
Piel, S., 2018, Lund: Lund University: Faculty of Medicine. 77 p.
Research output: Thesis › Doctoral Thesis (compilation)

Open Access
File

3 Participation in conference
1 Presentation

Mitochondrial Medicine
Piel, S. (Participant)
2016 May 4 → 2016 May 6
Activity: Participating in or organising an event › Participation in conference
Summer school on Mitochondrial Physiology
Piel, S. (Speaker)
2015 Aug 18 → 2015 Aug 20
Activity: Talk or presentation › Presentation
The United Mitochondrial Disease Foundation Symposium 2014
Piel, S. (Participant)
2014 Jun 4 → 2014 Jun 7
Activity: Participating in or organising an event › Participation in conference

Cite this

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title = "Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.",

abstract = "Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.",

author = "Sarah Piel and Johannes Ehinger and Eskil Elmer and Magnus Hansson",

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N2 - Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.

AB - Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.

U2 - 10.1111/apha.12311

DO - 10.1111/apha.12311

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JO - Acta Physiologica

JF - Acta Physiologica

IS - 1

ER -

Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.

Abstract

Subject classification (UKÄ)

Access to Document

Fingerprint

Research output

Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production

Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse.

Activities

Mitochondrial Medicine

Summer school on Mitochondrial Physiology

The United Mitochondrial Disease Foundation Symposium 2014

Cite this