Method for Programming Differentiated Cells into Hematopoietic Stem Cells

Ihor R. Lemischka; Kateri Moore; Filipe Pereira

Method for Programming Differentiated Cells into Hematopoietic Stem Cells

Ihor R. Lemischka (Inventor), Kateri Moore (Inventor), Filipe Pereira (Inventor)

Icahn School of Medicine at Mount Sinai

Research output: Patent

Abstract

The disclosure relates to the development of methods for making hematopoietic stem cells from differentiated cells by introducing and expressing transcription factors. More particularly, the disclosure provides methods for redirecting differentiated cells to a hematopoietic stem cell state or to a hemogenic endothelial cell state by direct programming with specific combinations of transcription factors.

Original language	English
Patent number	WO2013116307A1
Filing date	2013/01/30
Publication status	Published - 2017
Externally published	Yes

Subject classification (UKÄ)

Cell and Molecular Biology

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title = "Method for Programming Differentiated Cells into Hematopoietic Stem Cells",

abstract = "The disclosure relates to the development of methods for making hematopoietic stem cells from differentiated cells by introducing and expressing transcription factors. More particularly, the disclosure provides methods for redirecting differentiated cells to a hematopoietic stem cell state or to a hemogenic endothelial cell state by direct programming with specific combinations of transcription factors.",

author = "Lemischka, \{Ihor R.\} and Kateri Moore and Filipe Pereira",

year = "2017",

language = "English",

type = "Patent",

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TY - PAT

T1 - Method for Programming Differentiated Cells into Hematopoietic Stem Cells

AU - Lemischka, Ihor R.

AU - Moore, Kateri

AU - Pereira, Filipe

PY - 2017

Y1 - 2017

N2 - The disclosure relates to the development of methods for making hematopoietic stem cells from differentiated cells by introducing and expressing transcription factors. More particularly, the disclosure provides methods for redirecting differentiated cells to a hematopoietic stem cell state or to a hemogenic endothelial cell state by direct programming with specific combinations of transcription factors.

AB - The disclosure relates to the development of methods for making hematopoietic stem cells from differentiated cells by introducing and expressing transcription factors. More particularly, the disclosure provides methods for redirecting differentiated cells to a hematopoietic stem cell state or to a hemogenic endothelial cell state by direct programming with specific combinations of transcription factors.

M3 - Patent

M1 - WO2013116307A1

Y2 - 2013/01/30

ER -

Method for Programming Differentiated Cells into Hematopoietic Stem Cells

Abstract

Subject classification (UKÄ)

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