Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.

Stine A Danielsen, Guro E Lind, Matthias Kolberg, Maren Høland, Bodil Bjerkehagen, Kirsten Sundby Hall, Eva van den Berg, Fredrik Mertens, Sigbjørn Smeland, Piero Picci, Ragnhild A Lothe

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Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled.
Original languageEnglish
Pages (from-to)63-69
JournalNeuro-Oncology
Volume17
Issue number1
DOIs
Publication statusPublished - 2015

Subject classification (UKÄ)

  • Medical Genetics

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