Methylation and loss of secreted frizzled-related protein 3 enhances melanoma cell migration and invasion.

Elin Ekström, Victoria Sherwood, Tommy Andersson

Research output: Contribution to journalArticlepeer-review

40 Citations (SciVal)
104 Downloads (Pure)

Abstract

Wnt signaling is important in development and can also contribute to the initiation and progression of cancer. The Secreted Frizzled Related Proteins (SFRPs) constitute a family of Wnt modulators, crucial for controlling Wnt signaling. Here we investigate the expression and role of SFRP3 in melanoma.
Original languageEnglish
Article numbere18674
JournalPLoS ONE
Volume6
Issue number4
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Cancer and Oncology

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