Microbeam radiation therapy - Grid therapy and beyond: A clinical perspective

Elisabeth Schültke; Jacques Balosso; Thomas Breslin; Guido Cavaletti; Valentin Djonov; Francois Esteve; Michael Grotzer; Guido Hildebrandt; Alexander Valdman; Jean Laissue

doi:10.1259/bjr.20170073

Microbeam radiation therapy - Grid therapy and beyond: A clinical perspective

Elisabeth Schültke, Jacques Balosso, Thomas Breslin, Guido Cavaletti, Valentin Djonov, Francois Esteve, Michael Grotzer, Guido Hildebrandt, Alexander Valdman, Jean Laissue

Tumor microenvironment

Research output: Contribution to journal › Review article › peer-review

Abstract

Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.

Original language	English
Article number	20170073
Journal	British Journal of Radiology
Volume	90
Issue number	1078
DOIs	https://doi.org/10.1259/bjr.20170073
Publication status	Published - 2017

Subject classification (UKÄ)

Radiology, Nuclear Medicine and Medical Imaging
Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1259/bjr.20170073

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title = "Microbeam radiation therapy - Grid therapy and beyond: A clinical perspective",

abstract = "Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.",

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T1 - Microbeam radiation therapy - Grid therapy and beyond

T2 - A clinical perspective

AU - Schültke, Elisabeth

AU - Balosso, Jacques

AU - Breslin, Thomas

AU - Cavaletti, Guido

AU - Djonov, Valentin

AU - Esteve, Francois

AU - Grotzer, Michael

AU - Hildebrandt, Guido

AU - Valdman, Alexander

AU - Laissue, Jean

PY - 2017

Y1 - 2017

N2 - Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.

AB - Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.

U2 - 10.1259/bjr.20170073

DO - 10.1259/bjr.20170073

M3 - Review article

C2 - 28749174

AN - SCOPUS:85030770188

SN - 0007-1285

VL - 90

JO - British Journal of Radiology

JF - British Journal of Radiology

IS - 1078

M1 - 20170073

ER -

Microbeam radiation therapy - Grid therapy and beyond: A clinical perspective

Abstract

Subject classification (UKÄ)

UN SDGs

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