Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

Ara Koh; Louise Mannerås-Holm; Na Oh Yunn; Peter M. Nilsson; Sung Ho Ryu; Antonio Molinaro; Rosie Perkins; J. Gustav Smith; Fredrik Bäckhed

doi:10.1016/j.cmet.2020.07.012

Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

Ara Koh, Louise Mannerås-Holm, Na Oh Yunn, Peter M. Nilsson, Sung Ho Ryu, Antonio Molinaro, Rosie Perkins, J. Gustav Smith, Fredrik Bäckhed

Research output: Contribution to journal › Article › peer-review

Abstract

Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.

Original language	English
Pages (from-to)	643-653
Number of pages	11
Journal	Cell Metabolism
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2020.07.012
Publication status	Published - 2020 Oct 6

Subject classification (UKÄ)

Physiology and Anatomy

Free keywords

AMPK
diabetes
imidazole propionate
individual variations
metformin
microbial metabolites
microbiota
p38γ

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2020.07.012Licence: CC BY-NC-ND

Cite this

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title = "Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation",

abstract = "Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.",

keywords = "AMPK, diabetes, imidazole propionate, individual variations, metformin, microbial metabolites, microbiota, p38γ",

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T1 - Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

AU - Koh, Ara

AU - Mannerås-Holm, Louise

AU - Yunn, Na Oh

AU - Nilsson, Peter M.

AU - Ryu, Sung Ho

AU - Molinaro, Antonio

AU - Perkins, Rosie

AU - Smith, J. Gustav

AU - Bäckhed, Fredrik

PY - 2020/10/6

Y1 - 2020/10/6

N2 - Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.

AB - Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.

KW - AMPK

KW - diabetes

KW - imidazole propionate

KW - individual variations

KW - metformin

KW - microbial metabolites

KW - microbiota

KW - p38γ

U2 - 10.1016/j.cmet.2020.07.012

DO - 10.1016/j.cmet.2020.07.012

M3 - Article

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AN - SCOPUS:85090062838

SN - 1550-4131

VL - 32

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EP - 653

JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -

Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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