Abstract
All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.
| Original language | English |
|---|---|
| Pages (from-to) | 251-254 |
| Journal | Planta Medica |
| Volume | 63 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1997 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Division of Clinical Chemistry and Pharmacology (013250300), Organic chemistry (S/LTH) (011001240)
Subject classification (UKÄ)
- Medicinal Chemistry
- Dermatology and Venereal Diseases
- Pharmacology and Toxicology
Free keywords
- Scented myrrh
- Commiphora guidotti
- Burseraceae
- sesquiterpenes
- T-cadinol
- smooth muscle relaxant