HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.

Original languageEnglish
Pages (from-to)241-256.e6
JournalCell Stem Cell
Issue number2
Early online date2020 Oct 20
Publication statusPublished - 2021

Bibliographical note

© 2020 The Authors. Published by Elsevier Inc.

Subject classification (UKÄ)

  • Cell and Molecular Biology

Free keywords

  • Aging
  • Hematopoietc Stem Cell
  • Lineage bias
  • Mitochondria
  • Mitochondrial Membrane Potential
  • Mitoquinol
  • Transcription Rate


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