HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.
Bibliographical note© 2020 The Authors. Published by Elsevier Inc.
Subject classification (UKÄ)
- Cell and Molecular Biology
- Hematopoietc Stem Cell
- Lineage bias
- Mitochondrial Membrane Potential
- Transcription Rate