Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

Els Mansell; Valgardur Sigurdsson; Elitza Deltcheva; John Brown; Chela James; Kenichi Miharada; Shamit Soneji; Jonas Larsson; Tariq Enver

doi:10.1016/j.stem.2020.09.018

Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

Els Mansell, Valgardur Sigurdsson, Elitza Deltcheva, John Brown, Chela James, Kenichi Miharada, Shamit Soneji, Jonas Larsson, Tariq Enver

University College London

Research output: Contribution to journal › Article › peer-review

Abstract

HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.

Original language	English
Pages (from-to)	241-256.e6
Journal	Cell Stem Cell
Volume	28
Issue number	2
Early online date	2020 Oct 20
DOIs	https://doi.org/10.1016/j.stem.2020.09.018
Publication status	Published - 2021

Bibliographical note

Subject classification (UKÄ)

Cell and Molecular Biology

Free keywords

Aging
Hematopoietc Stem Cell
Lineage bias
Mitochondria
Mitochondrial Membrane Potential
Mitoquinol
Transcription Rate

Access to Document

10.1016/j.stem.2020.09.018Licence: CC BY

Cite this

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abstract = "HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.",

keywords = "Aging, Hematopoietc Stem Cell, Lineage bias, Mitochondria, Mitochondrial Membrane Potential, Mitoquinol, Transcription Rate",

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AU - Mansell, Els

AU - Sigurdsson, Valgardur

AU - Deltcheva, Elitza

AU - Brown, John

AU - James, Chela

AU - Miharada, Kenichi

AU - Soneji, Shamit

AU - Larsson, Jonas

AU - Enver, Tariq

PY - 2021

Y1 - 2021

N2 - HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.

AB - HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.

KW - Aging

KW - Hematopoietc Stem Cell

KW - Lineage bias

KW - Mitochondria

KW - Mitochondrial Membrane Potential

KW - Mitoquinol

KW - Transcription Rate

UR - https://www.scopus.com/pages/publications/85095443376

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DO - 10.1016/j.stem.2020.09.018

M3 - Article

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AN - SCOPUS:85095443376

SN - 1934-5909

VL - 28

SP - 241-256.e6

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 2

ER -

Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

Abstract

Bibliographical note

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