MMP7 Expression in Colorectal Tumours of Different Stages

Andrea Polistena, Alessandra Cucina, Simona Dinicola, Christina Stene, Giuseppe Cavallaro, Antonio Ciardi, Gennaro Orlando, Rossella Arena, Giuseppe D'Ermo, Antonino Cavallaro, Louis Banka Johnson, Giorgio De Toma

Research output: Contribution to journalArticlepeer-review

30 Citations (SciVal)

Abstract

Background/Aim: Matrix metalloproteinases (MMPs) are involved in cancer biology. Expression of MMP7 (matrilysin) in colorectal cancer is associated with metastatic disease even though it is expressed in most tumour states. In the present study, our purpose was to analyze MMP7 in bowel and lymph nodes of different tumour stages and to evaluate its expression as a cancer biomarker. Patients and Methods: 28 patients surgically-treated for benign and malignant colorectal tumours were recruited and analyzed for MMP7 in tumoural tissue, lymph nodes and serum by histology, immunohistochemistry, ELISA and western blotting. Results: Immunohistochemistu showed prevalent expression of MMP7 in advanced cancer. A significant increase (p < 0.001) was evident in serum of stage III/IV cancers compared to both adenomas and non-metastatic disease. MMP7 was increased in cancer tissues with prevalence in stage I/II. Lymph nodes presented a significant increase of MMP7 (p < 0.05 adenoma vs. stage I/II and p < 0.001 vs. stage III/IV). Conclusion: MMP7 increases with dysplasia and cancer disease stage in tumour tissue as well as in the regional lymph nodes. It may be used as a complement in investigating suspected locally advanced cancer.
Original languageEnglish
Pages (from-to)105-110
JournalIn Vivo
Volume28
Issue number1
Publication statusPublished - 2014

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200)

Subject classification (UKÄ)

  • Cancer and Oncology

Keywords

  • Matrilysin
  • MMP7
  • colorectal cancer
  • adenoma
  • lymph nodes

Fingerprint

Dive into the research topics of 'MMP7 Expression in Colorectal Tumours of Different Stages'. Together they form a unique fingerprint.

Cite this