Modelling of Drug Release from Reservoir and Matrix Formulations - Multiple Unit Dosage Forms and Swelling and Dissolving Matrix Systems

Per Borgquist

Research output: ThesisDoctoral Thesis (compilation)

Abstract

In this work, mathematical models have been developed describing drug release from film-coated reservoir systems as well as drug release and polymer dissolution from swelling and dissolving polymer tablets. The model derivation of both systems is based on a mechanistic approach. The model describing drug release from reservoir systems, i.e. from single, film-coated pellets, was validated against experimental release data from single ethyl-cellulose-coated pellets. The model was also expanded to account for the simultaneous release from an ensemble of single pellets, i.e. a multiple-unit model. This study was verified against release data from ensembles of ethyl-cellulose-coated pellets. Qualitative studies using SEM on the film-coated pellets together with the information gained from the model evaluation of the experimental release data, indicated that a major release mechanism from these pellets is drug transport through cracks and holes in the polymer film. This finding confirms the view that it is essential to obtain information on release characteristics on the single-unit level in order to increase our knowledge concerning release-controlling mechanisms.The model for polymer swelling and dissolution, i.e. the polymer dissolution model, and the model for drug release from a swelling and dissolving polymer matrix, i.e. the drug release model, are based on mass transfer in cylindrical geometry. Diffusive and convective contributions to mass transfer are accounted for. The polymer dissolution model was fitted to experimental polymer dissolution and front position data of the dissolution of poly (ethylene oxide). The information gained from fitting was applied to the drug release model, which was validated against drug release data for a soluble drug and a slightly soluble drug. It was concluded that the convective contribution to drug mass transfer can be of considerable importance, leading to erroneous fitting results if neglected.
Original languageEnglish
QualificationDoctor
Awarding Institution
  • Division of Chemical Engineering
Supervisors/Advisors
  • Axelsson, Anders, Supervisor
Award date2005 Feb 4
Publisher
ISBN (Print)91-628-6374-6
Publication statusPublished - 2005

Bibliographical note

Defence details

Date: 2005-02-04
Time: 10:30
Place: Kemicentrum, Getingevägen 60, Lund, hörsal A

External reviewer(s)

Name: Siepmann, Juergen
Title: Professor
Affiliation: College of Pharmacy Université de Lille 2 3, rue du Professor Laguesse, B.P. 83 59006 Lille Cedex, F

---

Subject classification (UKÄ)

  • Chemical Engineering

Free keywords

  • swelling
  • XEDS
  • Chemical technology and engineering
  • Kemiteknik och kemisk teknologi
  • Polymer technology
  • biopolymers
  • Polymerteknik
  • Pharmaceutical and related technologies
  • Läkemedelsteknik och relaterad teknik
  • simulation
  • single pellet
  • single-unit release
  • SEM
  • reservoir system
  • poly (ethylene oxide)
  • film-coated
  • matrix
  • mathematical model
  • diffusion
  • pellet shape
  • controlled release
  • polymer dissolution
  • modelling
  • ethyl cellulose
  • Coating
  • multiple-unit release

Fingerprint

Dive into the research topics of 'Modelling of Drug Release from Reservoir and Matrix Formulations - Multiple Unit Dosage Forms and Swelling and Dissolving Matrix Systems'. Together they form a unique fingerprint.

Cite this