Abstract
Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.
Original language | English |
---|---|
Pages (from-to) | 48-60 |
Number of pages | 13 |
Journal | RSC Drug Discovery Series |
Volume | 2019-January |
Issue number | 66 |
DOIs | |
Publication status | Published - 2019 |
Subject classification (UKÄ)
- Ophthalmology