Modulation of Calcium Overload and Calpain Activity

François Paquet-Durand, Per Ekström, Valeria Marigo

Research output: Contribution to journalArticlepeer-review


Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.

Original languageEnglish
Pages (from-to)48-60
Number of pages13
JournalRSC Drug Discovery Series
Issue number66
Publication statusPublished - 2019

Subject classification (UKÄ)

  • Ophthalmology


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