Modulation of Calcium Overload and Calpain Activity

François Paquet-Durand; Per Ekström; Valeria Marigo

doi:10.1039/9781788013666-00048

Modulation of Calcium Overload and Calpain Activity

François Paquet-Durand, Per Ekström, Valeria Marigo

Retinal degeneration: Molecular Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Fluxes of calcium ions (Ca²⁺) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca²⁺ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca²⁺ homeostasis disruption and stimulation of Ca²⁺ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca²⁺ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.

Original language	English
Pages (from-to)	48-60
Number of pages	13
Journal	RSC Drug Discovery Series
Volume	2019-January
Issue number	66
DOIs	https://doi.org/10.1039/9781788013666-00048
Publication status	Published - 2019

Subject classification (UKÄ)

Ophthalmology

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10.1039/9781788013666-00048

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title = "Modulation of Calcium Overload and Calpain Activity",

abstract = "Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.",

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AB - Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.

U2 - 10.1039/9781788013666-00048

DO - 10.1039/9781788013666-00048

M3 - Article

AN - SCOPUS:85056592063

SN - 2041-3203

VL - 2019-January

SP - 48

EP - 60

JO - RSC Drug Discovery Series

JF - RSC Drug Discovery Series

IS - 66

ER -

Modulation of Calcium Overload and Calpain Activity

Abstract

Subject classification (UKÄ)

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