Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.

Thoas Fioretos; Sverre Heim; Stanislaw Garwicz; J Ludvigsson; Felix Mitelman

Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.

Thoas Fioretos, Sverre Heim, Stanislaw Garwicz, J Ludvigsson, Felix Mitelman

Research output: Contribution to journal › Article › peer-review

Abstract

The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).

Original language	English
Pages (from-to)	723-725
Journal	Leukemia
Volume	6
Issue number	7
Publication status	Published - 1992

Subject classification (UKÄ)

Cancer and Oncology

1 Doctoral Thesis (compilation)

Molecular Genetic Studies of Ph-positive Leukemias and the BCR and ABL Genes
Fioretos, T., 1996, Department of Clinical Genetics, Lund University. 60 p.
Research output: Thesis › Doctoral Thesis (compilation)

Cite this

@article{82f19ac1e6c743f4a0487fbd866b7574,

title = "Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.",

abstract = "The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).",

author = "Thoas Fioretos and Sverre Heim and Stanislaw Garwicz and J Ludvigsson and Felix Mitelman",

year = "1992",

language = "English",

volume = "6",

pages = "723--725",

journal = "Leukemia",

issn = "1476-5551",

publisher = "Nature Publishing Group",

number = "7",

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TY - JOUR

T1 - Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.

AU - Fioretos, Thoas

AU - Heim, Sverre

AU - Garwicz, Stanislaw

AU - Ludvigsson, J

AU - Mitelman, Felix

PY - 1992

Y1 - 1992

N2 - The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).

AB - The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).

M3 - Article

VL - 6

SP - 723

EP - 725

JO - Leukemia

JF - Leukemia

SN - 1476-5551

IS - 7

ER -

Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.

Abstract

Subject classification (UKÄ)

Fingerprint

Research output

Molecular Genetic Studies of Ph-positive Leukemias and the BCR and ABL Genes

Cite this