Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.

Thoas Fioretos, Sverre Heim, Stanislaw Garwicz, J Ludvigsson, Felix Mitelman

Research output: Contribution to journalArticlepeer-review


The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).
Original languageEnglish
Pages (from-to)723-725
Issue number7
Publication statusPublished - 1992

Subject classification (UKÄ)

  • Cancer and Oncology


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