Abstract
A lambda gt11 clone encoding prostate specific antigen has been isolated from a human prostate cDNA library. The cDNA insert of 1415 nucleotides hybridizes specifically to a prostate mRNA species of 1.5 kb. The nucleotide sequence codes for part of a signal peptide, a short propiece and the mature protein of 237 amino acid residues. The Mr for the non-glycosylated protein was 26,089. One potential site for N-linked carbohydrate attachment was identified. The primary structure shows extensive homology with proteases of the kallikrein family.
Original language | English |
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Pages (from-to) | 317-22 |
Journal | FEBS Letters |
Volume | 214 |
Issue number | 2 |
Publication status | Published - 1987 |
Bibliographical note
2Subject classification (UKÄ)
- Medicinal Chemistry
Free keywords
- Non-U.S. Gov't
- Research Support
- Prostate-Specific Antigen
- Prostate/immunology
- Male
- Humans
- DNA/*genetics
- Molecular
- Cloning
- Base Sequence
- Amino Acid Sequence
- Antigens/*genetics