Molecular cloning of human prostate specific antigen cDNA

Research output: Contribution to journalArticlepeer-review

Abstract

A lambda gt11 clone encoding prostate specific antigen has been isolated from a human prostate cDNA library. The cDNA insert of 1415 nucleotides hybridizes specifically to a prostate mRNA species of 1.5 kb. The nucleotide sequence codes for part of a signal peptide, a short propiece and the mature protein of 237 amino acid residues. The Mr for the non-glycosylated protein was 26,089. One potential site for N-linked carbohydrate attachment was identified. The primary structure shows extensive homology with proteases of the kallikrein family.
Original languageEnglish
Pages (from-to)317-22
JournalFEBS Letters
Volume214
Issue number2
Publication statusPublished - 1987

Bibliographical note

2

Subject classification (UKÄ)

  • Medicinal Chemistry

Free keywords

  • Non-U.S. Gov't
  • Research Support
  • Prostate-Specific Antigen
  • Prostate/immunology
  • Male
  • Humans
  • DNA/*genetics
  • Molecular
  • Cloning
  • Base Sequence
  • Amino Acid Sequence
  • Antigens/*genetics

Fingerprint

Dive into the research topics of 'Molecular cloning of human prostate specific antigen cDNA'. Together they form a unique fingerprint.

Cite this