Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)

JD Wilkinson, S Shaw, KE Andersen, FM Brandao, DP Bruynzeel, Magnus Bruze, JMG Camarasa, TL Diepgen, G Ducombs, PJ Frosch, A Goossens, JM Lachappelle, A Lahti, T Menne, S Seidenari, A Tosti, JE Wahlberg

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221 Citations (SciVal)


A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
Original languageEnglish
Pages (from-to)207-210
JournalContact Dermatitis
Issue number4
Publication statusPublished - 2002

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases


  • diazolidinyl urea
  • formaldehyde
  • imidazolidinyl urea
  • methyldibromoglutaronitrile
  • patch test sensitization
  • parabens
  • preservatives
  • quaternium-15
  • 5-chloro-2-methyl-4-isothiazolin-3-one+2-methyl-4-isothiazolin-3-one


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