Monitoring Low Molecular Weight Heparins at Therapeutic Levels: Dose-Responses of, and Correlations and Differences between aPTT, Anti-Factor Xa and Thrombin Generation Assays.

Owain Thomas; Emanuel Lybeck; Karin Strandberg; Nahreen Tynngård; Ulf Schött

doi:10.1371/journal.pone.0116835

Monitoring Low Molecular Weight Heparins at Therapeutic Levels: Dose-Responses of, and Correlations and Differences between aPTT, Anti-Factor Xa and Thrombin Generation Assays.

Owain Thomas, Emanuel Lybeck, Karin Strandberg, Nahreen Tynngård, Ulf Schött

Research output: Contribution to journal › Article › peer-review

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Abstract

Low molecular weight heparins (LMWH's) are used to prevent and treat thrombosis. Tests for monitoring LMWH's include anti-factor Xa (anti-FXa), activated partial thromboplastin time (aPTT) and thrombin generation. Anti-FXa is the current gold standard despite LMWH's varying affinities for FXa and thrombin.

Original language	English
Article number	e0116835
Journal	PLoS ONE
Volume	10
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0116835
Publication status	Published - 2015

Subject classification (UKÄ)

Anesthesiology and Intensive Care
Hematology
Medicinal Chemistry

Access to Document

10.1371/journal.pone.0116835

PLoS__Thomas_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25625201?dopt=Abstract

1 Doctoral Thesis (compilation)

Haemostatic safety in epidural analgesia
THOMAS, O., 2016, Lund: Lund University: Faculty of Medicine. 72 p.
Research output: Thesis › Doctoral Thesis (compilation)

Open Access
File

2 Finished

Haemostatic Safety in Epidural Analgesia
Thomas, O. (Research student), Schött, U. (PI), Flisberg, P. (PI) & Frigyesi, A. (PI)
2012/01/02 → 2016/11/03
Project: Dissertation
Koagulation vid kirurgi och kritisk sjukdom
Schött, U. (PI)
1990/05/01 → 2019/03/31
Project: Research

1 Supervision of masters students

Tinzaparin and enoxaparin in vitro dose response effects on different whole blood and plasma based assays
Thomas, O. (Joint first/primary/lead supervisor) & Schött, U. (Joint first/primary/lead supervisor)
2014 Jan → 2014 Jun
Activity: Examination and supervision › Supervision of masters students

Cite this

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abstract = "Low molecular weight heparins (LMWH's) are used to prevent and treat thrombosis. Tests for monitoring LMWH's include anti-factor Xa (anti-FXa), activated partial thromboplastin time (aPTT) and thrombin generation. Anti-FXa is the current gold standard despite LMWH's varying affinities for FXa and thrombin.",

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AU - Tynngård, Nahreen

AU - Schött, Ulf

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Monitoring Low Molecular Weight Heparins at Therapeutic Levels: Dose-Responses of, and Correlations and Differences between aPTT, Anti-Factor Xa and Thrombin Generation Assays.

Abstract

Subject classification (UKÄ)

Access to Document

Fingerprint

Research output

Haemostatic safety in epidural analgesia

Projects

Haemostatic Safety in Epidural Analgesia

Koagulation vid kirurgi och kritisk sjukdom

Activities

Tinzaparin and enoxaparin in vitro dose response effects on different whole blood and plasma based assays

Cite this