TY - JOUR
T1 - Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats
AU - Nguyen, Thao Duy
AU - Watanabe, Ayako
AU - Burleigh, Stephen
AU - Ghaffarzadegan, Tannaz
AU - Kanklai, Jirapat
AU - Prykhodko, Olena
AU - Hållenius, Frida
AU - Nyman, Margareta
PY - 2022
Y1 - 2022
N2 - Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain
fatty acids (SCFAs), have been shown to positively influence lipid
profile and biomarkers in the gut and brain. This study examined whether
MB and MV in high-fat diets, affected microbiota composition and
gut–blood–brain markers in apolipoprotein E deficient (ApoE-/-) rats, a
model for studies of lipid-associated disorders, and neurodegenerative
processes in Alzheimer’s disease (AD). ApoE-/- rats fed MB and MV
increased Tenericutes and the brain neurotransmitter
γ-aminobutyric acid (GABA), while the blood stress hormone
corticosterone decreased compared to control rats. Only rats that
received MB showed a significant increase in cholic acid and Adlercreutzia in the caecum. In rats fed MV, the decrease of Proteobacteria
was associated with decreased corticosterone levels. Conclusively,
dietary supplementation of SCFA glycerol esters can modulate
gut–blood–brain markers and alter gut microbiota composition in ApoE-/-
rats, suggesting that SCFAs also could counteract lipid
disorders-related diseases.
AB - Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain
fatty acids (SCFAs), have been shown to positively influence lipid
profile and biomarkers in the gut and brain. This study examined whether
MB and MV in high-fat diets, affected microbiota composition and
gut–blood–brain markers in apolipoprotein E deficient (ApoE-/-) rats, a
model for studies of lipid-associated disorders, and neurodegenerative
processes in Alzheimer’s disease (AD). ApoE-/- rats fed MB and MV
increased Tenericutes and the brain neurotransmitter
γ-aminobutyric acid (GABA), while the blood stress hormone
corticosterone decreased compared to control rats. Only rats that
received MB showed a significant increase in cholic acid and Adlercreutzia in the caecum. In rats fed MV, the decrease of Proteobacteria
was associated with decreased corticosterone levels. Conclusively,
dietary supplementation of SCFA glycerol esters can modulate
gut–blood–brain markers and alter gut microbiota composition in ApoE-/-
rats, suggesting that SCFAs also could counteract lipid
disorders-related diseases.
U2 - 10.1038/s41598-022-19502-z
DO - 10.1038/s41598-022-19502-z
M3 - Article
C2 - 36104381
SN - 2045-2322
VL - 12
JO - Scientific Reports
JF - Scientific Reports
M1 - 15454
ER -