TY - JOUR
T1 - Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle
AU - Korosec, Chapin S.
AU - Unksov, Ivan N.
AU - Surendiran, Pradheebha
AU - Lyttleton, Roman
AU - Curmi, Paul M.G.
AU - Angstmann, Christopher N.
AU - Eichhorn, Ralf
AU - Linke, Heiner
AU - Forde, Nancy R.
PY - 2024
Y1 - 2024
N2 - Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins – the building blocks selected by nature – to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular motor comprised of a spherical hub decorated with proteases. Its “burnt-bridge” motion is directed by cleavage of a peptide lawn, promoting motion towards unvisited substrate. We find that Lawnmowers exhibit directional motion with average speeds of up to 80 nm/s, comparable to biological motors. By selectively patterning the peptide lawn on microfabricated tracks, we furthermore show that the Lawnmower is capable of track-guided motion. Our work opens an avenue towards nanotechnology applications of artificial protein motors.
AB - Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins – the building blocks selected by nature – to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular motor comprised of a spherical hub decorated with proteases. Its “burnt-bridge” motion is directed by cleavage of a peptide lawn, promoting motion towards unvisited substrate. We find that Lawnmowers exhibit directional motion with average speeds of up to 80 nm/s, comparable to biological motors. By selectively patterning the peptide lawn on microfabricated tracks, we furthermore show that the Lawnmower is capable of track-guided motion. Our work opens an avenue towards nanotechnology applications of artificial protein motors.
U2 - 10.1038/s41467-024-45570-y
DO - 10.1038/s41467-024-45570-y
M3 - Article
C2 - 38396042
AN - SCOPUS:85185909129
SN - 2041-1723
VL - 15
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 1511
ER -