Mucosal exudation of plasma is a noninjurious intestinal defense mechanism

C G Persson; B Gustafsson; Jonas Erjefält; Frank Sundler

doi:10.1111/j.1398-9995.1993.tb00752.x

Mucosal exudation of plasma is a noninjurious intestinal defense mechanism

C G Persson, B Gustafsson, Jonas Erjefält, Frank Sundler

Research output: Contribution to journal › Article › peer-review

Abstract

We have demonstrated in sensitized rats that the immediate response to endointestinal challenge with allergen (10(-6) M ovalbumin) is characterized by mucosal exudation of plasma with little or no concomitant change in the mucosal absorption capacity. The luminal entry of plasma macromolecules also leaves the light microscopic structure and the ultrastructure of the mucosa unaffected. It is possible that the plasticity of epithelial zonulae occludens allows a noninjurious and unidirectional paracellular flux of extravasated plasma into the gut lumen. We propose that inflammatory-stimulus-induced mucosal exudation of plasma belongs to the first-line defense mechanisms of the intact lining of the intestine.

Original language	English
Pages (from-to)	581-586
Journal	Allergy
Volume	48
Issue number	8
DOIs	https://doi.org/10.1111/j.1398-9995.1993.tb00752.x
Publication status	Published - 1993

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Airway Inflammation and Immunology (013212038)

Subject classification (UKÄ)

Respiratory Medicine and Allergy

Free keywords

endointestinal allergen challenge
epithelial integrity
luminal entry of plasma
mucosal exudation

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10.1111/j.1398-9995.1993.tb00752.x

Cite this

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title = "Mucosal exudation of plasma is a noninjurious intestinal defense mechanism",

abstract = "We have demonstrated in sensitized rats that the immediate response to endointestinal challenge with allergen (10(-6) M ovalbumin) is characterized by mucosal exudation of plasma with little or no concomitant change in the mucosal absorption capacity. The luminal entry of plasma macromolecules also leaves the light microscopic structure and the ultrastructure of the mucosa unaffected. It is possible that the plasticity of epithelial zonulae occludens allows a noninjurious and unidirectional paracellular flux of extravasated plasma into the gut lumen. We propose that inflammatory-stimulus-induced mucosal exudation of plasma belongs to the first-line defense mechanisms of the intact lining of the intestine.",

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author = "Persson, {C G} and B Gustafsson and Jonas Erjef{\"a}lt and Frank Sundler",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Airway Inflammation and Immunology (013212038)",

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doi = "10.1111/j.1398-9995.1993.tb00752.x",

language = "English",

volume = "48",

pages = "581--586",

journal = "Allergy",

issn = "1398-9995",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Mucosal exudation of plasma is a noninjurious intestinal defense mechanism

AU - Persson, C G

AU - Gustafsson, B

AU - Erjefält, Jonas

AU - Sundler, Frank

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Airway Inflammation and Immunology (013212038)

PY - 1993

Y1 - 1993

N2 - We have demonstrated in sensitized rats that the immediate response to endointestinal challenge with allergen (10(-6) M ovalbumin) is characterized by mucosal exudation of plasma with little or no concomitant change in the mucosal absorption capacity. The luminal entry of plasma macromolecules also leaves the light microscopic structure and the ultrastructure of the mucosa unaffected. It is possible that the plasticity of epithelial zonulae occludens allows a noninjurious and unidirectional paracellular flux of extravasated plasma into the gut lumen. We propose that inflammatory-stimulus-induced mucosal exudation of plasma belongs to the first-line defense mechanisms of the intact lining of the intestine.

AB - We have demonstrated in sensitized rats that the immediate response to endointestinal challenge with allergen (10(-6) M ovalbumin) is characterized by mucosal exudation of plasma with little or no concomitant change in the mucosal absorption capacity. The luminal entry of plasma macromolecules also leaves the light microscopic structure and the ultrastructure of the mucosa unaffected. It is possible that the plasticity of epithelial zonulae occludens allows a noninjurious and unidirectional paracellular flux of extravasated plasma into the gut lumen. We propose that inflammatory-stimulus-induced mucosal exudation of plasma belongs to the first-line defense mechanisms of the intact lining of the intestine.

KW - endointestinal allergen challenge

KW - epithelial integrity

KW - luminal entry of plasma

KW - mucosal exudation

U2 - 10.1111/j.1398-9995.1993.tb00752.x

DO - 10.1111/j.1398-9995.1993.tb00752.x

M3 - Article

SN - 1398-9995

VL - 48

SP - 581

EP - 586

JO - Allergy

JF - Allergy

IS - 8

ER -

Mucosal exudation of plasma is a noninjurious intestinal defense mechanism

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

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