Multifaceted role of the ubiquitin ligase Itch in immune regulation.

K Venuprasad; Minghui Zeng; Scott L Baughan; Ramin Massoumi

doi:10.1038/icb.2014.118

Multifaceted role of the ubiquitin ligase Itch in immune regulation.

K Venuprasad, Minghui Zeng, Scott L Baughan, Ramin Massoumi

Division of Translational Cancer Research

Research output: Contribution to journal › Review article › peer-review

Abstract

The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015; doi:10.1038/icb.2014.118.

Original language	English
Pages (from-to)	452-460
Journal	Immunology and Cell Biology
Volume	93
Issue number	5
DOIs	https://doi.org/10.1038/icb.2014.118
Publication status	Published - 2015

Subject classification (UKÄ)

Immunology

Access to Document

10.1038/icb.2014.118

http://www.ncbi.nlm.nih.gov/pubmed/25582340?dopt=Abstract

Cite this

@article{9f0b33cebae84d7b995f73d0ca36c25e,

title = "Multifaceted role of the ubiquitin ligase Itch in immune regulation.",

abstract = "The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015; doi:10.1038/icb.2014.118.",

author = "K Venuprasad and Minghui Zeng and Baughan, {Scott L} and Ramin Massoumi",

year = "2015",

doi = "10.1038/icb.2014.118",

language = "English",

volume = "93",

pages = "452--460",

journal = "Immunology and Cell Biology",

issn = "1440-1711",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Multifaceted role of the ubiquitin ligase Itch in immune regulation.

AU - Venuprasad, K

AU - Zeng, Minghui

AU - Baughan, Scott L

AU - Massoumi, Ramin

PY - 2015

Y1 - 2015

N2 - The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015; doi:10.1038/icb.2014.118.

AB - The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015; doi:10.1038/icb.2014.118.

U2 - 10.1038/icb.2014.118

DO - 10.1038/icb.2014.118

M3 - Review article

C2 - 25582340

SN - 1440-1711

VL - 93

SP - 452

EP - 460

JO - Immunology and Cell Biology

JF - Immunology and Cell Biology

IS - 5

ER -

Multifaceted role of the ubiquitin ligase Itch in immune regulation.

Abstract

Subject classification (UKÄ)

Access to Document

Fingerprint

Cite this