TY - JOUR
T1 - Multimodal Detection of Iron Oxide Nanoparticles in Rat Lymph Nodes Using Magnetomotive Ultrasound Imaging and Magnetic Resonance Imaging
AU - Evertsson, Maria
AU - Kjellman, Pontus
AU - Cinthio, Magnus
AU - Fredriksson, Sarah
AU - in 't Zandt, René
AU - Persson, Hans W
AU - Jansson, Tomas
PY - 2014
Y1 - 2014
N2 - Detection and removal of sentinel lymph nodes (SLN) is important in the diagnosis and treatment of cancer. The SLN is the first regional lymph node draining the primary tumor, and if the cancer has spread, it is most likely to find metastases in the SLN. In this study, we have for the first time been able to image the very same contrast agent, superparamagnetic iron oxide nanoparticles (SPIO-NPs), in rat SLNs by using both our frequency-and phase-gated magnetomotive ultrasound (MMUS) algorithm and conventional magnetic resonance imaging (MRI); MMUS post mortem, MRI in vivo. For both higher NP-concentration and smaller NPs, we found that the MMUS data showed a larger magnetomotive displacement (1.56 +/- 0.43 and 1.94 +/- 0.54 times larger, respectively) and that the MR-images were affected to a higher degree. The MMUS displacement also increased with lower excitation frequency (1.95 +/- 0.64 times larger for 5 Hz compared with 15 Hz) and higher excitation voltage (2.95 +/- 1.44 times larger for 30 V compared with 10 V). The results show that MMUS has potential to be used as bedside guidance during SLN surgery, imaging the same particles that were used in prior staging with other imaging techniques.
AB - Detection and removal of sentinel lymph nodes (SLN) is important in the diagnosis and treatment of cancer. The SLN is the first regional lymph node draining the primary tumor, and if the cancer has spread, it is most likely to find metastases in the SLN. In this study, we have for the first time been able to image the very same contrast agent, superparamagnetic iron oxide nanoparticles (SPIO-NPs), in rat SLNs by using both our frequency-and phase-gated magnetomotive ultrasound (MMUS) algorithm and conventional magnetic resonance imaging (MRI); MMUS post mortem, MRI in vivo. For both higher NP-concentration and smaller NPs, we found that the MMUS data showed a larger magnetomotive displacement (1.56 +/- 0.43 and 1.94 +/- 0.54 times larger, respectively) and that the MR-images were affected to a higher degree. The MMUS displacement also increased with lower excitation frequency (1.95 +/- 0.64 times larger for 5 Hz compared with 15 Hz) and higher excitation voltage (2.95 +/- 1.44 times larger for 30 V compared with 10 V). The results show that MMUS has potential to be used as bedside guidance during SLN surgery, imaging the same particles that were used in prior staging with other imaging techniques.
U2 - 10.1109/TUFFC.2014.3034
DO - 10.1109/TUFFC.2014.3034
M3 - Article
SN - 0885-3010
VL - 61
SP - 1276
EP - 1283
JO - IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
IS - 8
ER -