Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles

Pontus Svenmarker; Can Xu; Haichun Liu; Xia Wu; Stefan Andersson-Engels

doi:10.1063/1.4863960

Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles

Pontus Svenmarker, Can Xu, Haichun Liu, Xia Wu, Stefan Andersson-Engels

Atomic Physics

Umeå University

Research output: Contribution to journal › Article › peer-review

Abstract

We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information. (C) 2014 AIP Publishing LLC.

Original language	English
Article number	073703
Journal	Applied Physics Letters
Volume	104
Issue number	7
DOIs	https://doi.org/10.1063/1.4863960
Publication status	Published - 2014

Subject classification (UKÄ)

Atom and Molecular Physics and Optics

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10.1063/1.4863960

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title = "Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles",

abstract = "We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information. (C) 2014 AIP Publishing LLC.",

author = "Pontus Svenmarker and Can Xu and Haichun Liu and Xia Wu and Stefan Andersson-Engels",

year = "2014",

doi = "10.1063/1.4863960",

language = "English",

volume = "104",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics (AIP)",

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AU - Svenmarker, Pontus

AU - Xu, Can

AU - Liu, Haichun

AU - Wu, Xia

AU - Andersson-Engels, Stefan

PY - 2014

Y1 - 2014

N2 - We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information. (C) 2014 AIP Publishing LLC.

AB - We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information. (C) 2014 AIP Publishing LLC.

U2 - 10.1063/1.4863960

DO - 10.1063/1.4863960

M3 - Article

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VL - 104

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 7

M1 - 073703

ER -

Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles

Abstract

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