TY - JOUR
T1 - Myeloid-related protein 14 promote inflammation and injury in meningitis.
AU - Wache, Christina
AU - Klein, Matthias
AU - Ostergaard, Christian
AU - Angele, Barbara
AU - Häcker, Hans
AU - Pfister, Hans-Walter
AU - Pruenster, Monika
AU - Sperandio, Markus
AU - Leanderson, Tomas
AU - Roth, Johannes
AU - Vogl, Thomas
AU - Koedel, Uwe
PY - 2015
Y1 - 2015
N2 - Neutrophilic inflammation often persists over days despite efficient antibiotic treatment and contributes to brain damage in bacterial meningitis. We proposed here that MRP14, an abundant cytosolic protein in myeloid cells, acts as an endogenous danger signal, driving inflammation and aggravating tissue injury.
AB - Neutrophilic inflammation often persists over days despite efficient antibiotic treatment and contributes to brain damage in bacterial meningitis. We proposed here that MRP14, an abundant cytosolic protein in myeloid cells, acts as an endogenous danger signal, driving inflammation and aggravating tissue injury.
U2 - 10.1093/infdis/jiv028
DO - 10.1093/infdis/jiv028
M3 - Article
C2 - 25605866
SN - 1537-6613
VL - 212
SP - 247
EP - 257
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -