Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

O. Klementieva; J. Mathurin; A. Engdahl; R. Freitas; K. Willen; P. Uvdal; L. M. Miller; G. Gouras

doi:10.1109/IRMMW-THz.2018.8510376

Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

O. Klementieva, J. Mathurin, A. Engdahl, R. Freitas, K. Willen, P. Uvdal, L. M. Miller, G. Gouras

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

Abstract

Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.

Original language	English
Title of host publication	2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
Publisher	IEEE Computer Society
Volume	2018-September
ISBN (Electronic)	9781538638095
DOIs	https://doi.org/10.1109/IRMMW-THz.2018.8510376
Publication status	Published - 2018 Oct 29
Event	43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 - Nagoya, Japan Duration: 2018 Sept 9 → 2018 Sept 14

Conference

Conference	43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
Country/Territory	Japan
City	Nagoya
Period	2018/09/09 → 2018/09/14

Subject classification (UKÄ)

Neurosciences
Medical Imaging

Access to Document

10.1109/IRMMW-THz.2018.8510376

Cite this

Klementieva, O., Mathurin, J., Engdahl, A., Freitas, R., Willen, K., Uvdal, P., Miller, L. M., & Gouras, G. (2018). Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice. In 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 (Vol. 2018-September). Article 8510376 IEEE Computer Society. https://doi.org/10.1109/IRMMW-THz.2018.8510376

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title = "Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice",

abstract = "Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.",

author = "O. Klementieva and J. Mathurin and A. Engdahl and R. Freitas and K. Willen and P. Uvdal and Miller, {L. M.} and G. Gouras",

year = "2018",

month = oct,

day = "29",

doi = "10.1109/IRMMW-THz.2018.8510376",

language = "English",

volume = "2018-September",

booktitle = "2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018",

publisher = "IEEE Computer Society",

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note = "43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 ; Conference date: 09-09-2018 Through 14-09-2018",

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Klementieva, O, Mathurin, J, Engdahl, A, Freitas, R, Willen, K, Uvdal, P, Miller, LM & Gouras, G 2018, Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice. in 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. vol. 2018-September, 8510376, IEEE Computer Society, 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018, Nagoya, Japan, 2018/09/09. https://doi.org/10.1109/IRMMW-THz.2018.8510376

Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice. / Klementieva, O.; Mathurin, J.; Engdahl, A. et al.
2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. Vol. 2018-September IEEE Computer Society, 2018. 8510376.

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

TY - GEN

T1 - Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

AU - Klementieva, O.

AU - Mathurin, J.

AU - Engdahl, A.

AU - Freitas, R.

AU - Willen, K.

AU - Uvdal, P.

AU - Miller, L. M.

AU - Gouras, G.

PY - 2018/10/29

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N2 - Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.

AB - Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.

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DO - 10.1109/IRMMW-THz.2018.8510376

M3 - Paper in conference proceeding

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BT - 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018

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Y2 - 9 September 2018 through 14 September 2018

ER -

Klementieva O, Mathurin J, Engdahl A, Freitas R, Willen K, Uvdal P et al. Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice. In 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. Vol. 2018-September. IEEE Computer Society. 2018. 8510376 doi: 10.1109/IRMMW-THz.2018.8510376

Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

Abstract

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