Nanoassemblies from vitamin C derivatives

P. Lo Nostro; M. Ambrosi; E. Fratini; F. Ridi; E. Carretti; M. Lagi; V. Alfredsson; B. W. Ninham; P. Baglioni

Nanoassemblies from vitamin C derivatives

P. Lo Nostro, M. Ambrosi, E. Fratini, F. Ridi, E. Carretti, M. Lagi, V. Alfredsson, B. W. Ninham, P. Baglioni

Physical Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

Abstract

Vitamin C is one of the most effective natural antioxidants. However, due to its poor solubility in non-aqueous environments, its use is restricted to water-based systems. In order to extend its advantages to lipophilic media, vitamin C must be converted into amphiphilic derivatives. Two new vitamin C-based surfactants were synthesized: a bolaform derivative (1,12-diascorbyl dodecanedioate, BOLA12), and a double chain product (2-octyl-dodecanoyl6-0- ascorbic acid, 8ASC10). Once dispersed in water above 0.5% w/w, BOLA12 forms hollow nanotubes that transform into clear micellar solutions on heating. 8ASC10 is poorly soluble in aqueous media, but it dissolves easily in cyclohexane where it forms true organogels. Cryo-TEM, XRD, SAXS, conductivity, viscosity and DSC experiments were performed in order to study the aggregation properties and morphology of these nanoassemblies.

Original language	English
Title of host publication	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages	9-12
Number of pages	4
Volume	2
Publication status	Published - 2007 Aug 23
Event	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States Duration: 2007 May 20 → 2007 May 24

Conference

Conference	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
Country/Territory	United States
City	Santa Clara, CA
Period	2007/05/20 → 2007/05/24

Subject classification (UKÄ)

Physical Chemistry (including Surface- and Colloid Chemistry)

Free keywords

Antioxidant
Ascorbic acid
Nanoparticles
Organogel
Vitamin C

Cite this

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title = "Nanoassemblies from vitamin C derivatives",

abstract = "Vitamin C is one of the most effective natural antioxidants. However, due to its poor solubility in non-aqueous environments, its use is restricted to water-based systems. In order to extend its advantages to lipophilic media, vitamin C must be converted into amphiphilic derivatives. Two new vitamin C-based surfactants were synthesized: a bolaform derivative (1,12-diascorbyl dodecanedioate, BOLA12), and a double chain product (2-octyl-dodecanoyl6-0- ascorbic acid, 8ASC10). Once dispersed in water above 0.5% w/w, BOLA12 forms hollow nanotubes that transform into clear micellar solutions on heating. 8ASC10 is poorly soluble in aqueous media, but it dissolves easily in cyclohexane where it forms true organogels. Cryo-TEM, XRD, SAXS, conductivity, viscosity and DSC experiments were performed in order to study the aggregation properties and morphology of these nanoassemblies.",

keywords = "Antioxidant, Ascorbic acid, Nanoparticles, Organogel, Vitamin C",

author = "{Lo Nostro}, P. and M. Ambrosi and E. Fratini and F. Ridi and E. Carretti and M. Lagi and V. Alfredsson and Ninham, {B. W.} and P. Baglioni",

year = "2007",

month = aug,

day = "23",

language = "English",

isbn = "9781420063424",

volume = "2",

pages = "9--12",

booktitle = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings",

note = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 ; Conference date: 20-05-2007 Through 24-05-2007",

}

Lo Nostro, P, Ambrosi, M, Fratini, E, Ridi, F, Carretti, E, Lagi, M, Alfredsson, V, Ninham, BW & Baglioni, P 2007, Nanoassemblies from vitamin C derivatives. in 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings. vol. 2, pp. 9-12, 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Santa Clara, CA, United States, 2007/05/20.

TY - GEN

T1 - Nanoassemblies from vitamin C derivatives

AU - Lo Nostro, P.

AU - Ambrosi, M.

AU - Fratini, E.

AU - Ridi, F.

AU - Carretti, E.

AU - Lagi, M.

AU - Alfredsson, V.

AU - Ninham, B. W.

AU - Baglioni, P.

PY - 2007/8/23

Y1 - 2007/8/23

N2 - Vitamin C is one of the most effective natural antioxidants. However, due to its poor solubility in non-aqueous environments, its use is restricted to water-based systems. In order to extend its advantages to lipophilic media, vitamin C must be converted into amphiphilic derivatives. Two new vitamin C-based surfactants were synthesized: a bolaform derivative (1,12-diascorbyl dodecanedioate, BOLA12), and a double chain product (2-octyl-dodecanoyl6-0- ascorbic acid, 8ASC10). Once dispersed in water above 0.5% w/w, BOLA12 forms hollow nanotubes that transform into clear micellar solutions on heating. 8ASC10 is poorly soluble in aqueous media, but it dissolves easily in cyclohexane where it forms true organogels. Cryo-TEM, XRD, SAXS, conductivity, viscosity and DSC experiments were performed in order to study the aggregation properties and morphology of these nanoassemblies.

AB - Vitamin C is one of the most effective natural antioxidants. However, due to its poor solubility in non-aqueous environments, its use is restricted to water-based systems. In order to extend its advantages to lipophilic media, vitamin C must be converted into amphiphilic derivatives. Two new vitamin C-based surfactants were synthesized: a bolaform derivative (1,12-diascorbyl dodecanedioate, BOLA12), and a double chain product (2-octyl-dodecanoyl6-0- ascorbic acid, 8ASC10). Once dispersed in water above 0.5% w/w, BOLA12 forms hollow nanotubes that transform into clear micellar solutions on heating. 8ASC10 is poorly soluble in aqueous media, but it dissolves easily in cyclohexane where it forms true organogels. Cryo-TEM, XRD, SAXS, conductivity, viscosity and DSC experiments were performed in order to study the aggregation properties and morphology of these nanoassemblies.

KW - Antioxidant

KW - Ascorbic acid

KW - Nanoparticles

KW - Organogel

KW - Vitamin C

UR - http://www.scopus.com/inward/record.url?scp=34547973920&partnerID=8YFLogxK

M3 - Paper in conference proceeding

AN - SCOPUS:34547973920

SN - 9781420063424

SN - 9781420061833

VL - 2

SP - 9

EP - 12

BT - 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings

T2 - 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007

Y2 - 20 May 2007 through 24 May 2007

ER -

Nanoassemblies from vitamin C derivatives

Abstract

Conference

Subject classification (UKÄ)

Free keywords

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