Nanosphere induced gene expression in human dendritic cells

M Matsusaki, Kristina Larsson, T Akagi, Malin Lindstedt, M Akashi, Carl Borrebaeck

Research output: Contribution to journalArticlepeer-review


The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.
Original languageEnglish
Pages (from-to)2168-2173
JournalNano Letters
Issue number11
Publication statusPublished - 2005

Subject classification (UKÄ)

  • Nano Technology


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