Nanosphere induced gene expression in human dendritic cells

M Matsusaki; Kristina Larsson; T Akagi; Malin Lindstedt; M Akashi; Carl Borrebaeck

doi:10.1021/nl050541s

Nanosphere induced gene expression in human dendritic cells

M Matsusaki, Kristina Larsson, T Akagi, Malin Lindstedt, M Akashi, Carl Borrebaeck

Department of Immunotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.

Original language	English
Pages (from-to)	2168-2173
Journal	Nano Letters
Volume	5
Issue number	11
DOIs	https://doi.org/10.1021/nl050541s
Publication status	Published - 2005

Subject classification (UKÄ)

Nano-technology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/nl050541s

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title = "Nanosphere induced gene expression in human dendritic cells",

abstract = "The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.",

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AU - Matsusaki, M

AU - Larsson, Kristina

AU - Akagi, T

AU - Lindstedt, Malin

AU - Akashi, M

AU - Borrebaeck, Carl

PY - 2005

Y1 - 2005

N2 - The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.

AB - The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.

U2 - 10.1021/nl050541s

DO - 10.1021/nl050541s

M3 - Article

C2 - 16277447

SN - 1530-6992

VL - 5

SP - 2168

EP - 2173

JO - Nano Letters

JF - Nano Letters

IS - 11

ER -

Nanosphere induced gene expression in human dendritic cells

Abstract

Subject classification (UKÄ)

UN SDGs

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