Nanowire Biocompatibility in the Brain - Looking for a Needle in a 3D Stack.

Cecilia Eriksson Linsmeier; Christelle Prinz; Lina Pettersson; Philippe Caroff; Lars Samuelson; Jens Schouenborg; Lars Montelius; Nils Danielsen

doi:10.1021/nl902413x

Nanowire Biocompatibility in the Brain - Looking for a Needle in a 3D Stack.

Cecilia Eriksson Linsmeier, Christelle Prinz, Lina Pettersson, Philippe Caroff, Lars Samuelson, Jens Schouenborg, Lars Montelius, Nils Danielsen

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Abstract

We investigated the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry. The nanowires could be visualized in the scar by confocal microscopy (through the scattered laser light). For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain.

Original language	English
Pages (from-to)	4184-4190
Journal	Nano Letters
Volume	9
Issue number	12
DOIs	https://doi.org/10.1021/nl902413x
Publication status	Published - 2009

Subject classification (UKÄ)

Nano Technology

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10.1021/nl902413x

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title = "Nanowire Biocompatibility in the Brain - Looking for a Needle in a 3D Stack.",

abstract = "We investigated the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry. The nanowires could be visualized in the scar by confocal microscopy (through the scattered laser light). For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain.",

author = "{Eriksson Linsmeier}, Cecilia and Christelle Prinz and Lina Pettersson and Philippe Caroff and Lars Samuelson and Jens Schouenborg and Lars Montelius and Nils Danielsen",

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AU - Eriksson Linsmeier, Cecilia

AU - Prinz, Christelle

AU - Pettersson, Lina

AU - Caroff, Philippe

AU - Samuelson, Lars

AU - Schouenborg, Jens

AU - Montelius, Lars

AU - Danielsen, Nils

PY - 2009

Y1 - 2009

N2 - We investigated the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry. The nanowires could be visualized in the scar by confocal microscopy (through the scattered laser light). For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain.

AB - We investigated the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry. The nanowires could be visualized in the scar by confocal microscopy (through the scattered laser light). For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain.

U2 - 10.1021/nl902413x

DO - 10.1021/nl902413x

M3 - Article

C2 - 19845389

SN - 1530-6992

VL - 9

SP - 4184

EP - 4190

JO - Nano Letters

JF - Nano Letters

IS - 12

ER -

Nanowire Biocompatibility in the Brain - Looking for a Needle in a 3D Stack.

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