Natriuretic peptides as indicators of cardiac remodeling in hypertensive patients.

Martin Magnusson, Stefan Jovinge, Erik Rydberg, Bjorn Dahlof, Christian Hall, Olav Nielsen, Anders Grubb, Ronnie Willenheimer

Research output: Contribution to journalArticlepeer-review

3 Citations (SciVal)

Abstract

Aims. This study was performed to evaluate the relationship between three different natriuretic peptides and left ventricular mass, function and diameter, and kidney function in patients with hypertension. Methods. One hundred and thirty-nine patients with moderate hypertension were consecutively included. N-terminal brain natriuretic peptide (Nt-BNP), brain natriuretic peptide (BNP) and N-terminal pro-atrial natriuretic peptide (Nt-ANP) were analyzed. Cardiac remodeling was assessed by echocardiography (UCG) and glomerular filtration was estimated by cystatin C. Results. Patients were stratified into four groups with regard to the extent of cardiac remodeling: (1) no remodeling; (2) one of left ventricular hypertrophy, left ventricular dysfunction or left ventricular dilatation; (3) two of above and (4) all three parameters. All peptides differed significantly between the groups (all p<0.001), with a continuous stepwise increase from groups 1 through 4. Receiver operating characteristic analysis showed equal diagnostic performances for the detection of any cardiac abnormalities for Nt-BNP [area under curve, AUC= 0.63 (0.52-0.75), p= 0.026] and BNP [AUC= 0.64 (0.53-0.76), p= 0.019], both, however superior to Nt-ANP [AUC=0.59 (0.47-0.70), p= 0.139]. In multivariable linear regression analysis, all three indicators of cardiac remodeling were independently correlated with ln Nt-BNP and ln BNP, whereas only left ventricular diameter was independently correlated with ln Nt-ANP. Conclusions. Natriuretic peptide levels increased with increasing number of markers of cardiac remodeling. Nt-BNP and BNP are useful to discriminate between patients with regard to cardiac remodeling and might be considered a screening tool in order select patients eligible for further examination with UCG examination.
Original languageEnglish
Pages (from-to)196-203
JournalBlood Pressure
Volume18
DOIs
Publication statusPublished - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Division of Clinical Chemistry and Pharmacology (013250300), Stem Cell Center (013041110), Emergency medicine/Medicine/Surgery (013240200), Cardiology Research Group (013242120)

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

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