Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC)

U Broome; H Glaumann; Eva Lindström; L Loof; S Almer; Hanne Prytz; H Sandberg-Gertzen; Stefan Lindgren; Thomas Fork; G Jarnerot; R Olsson

doi:10.1016/S0168-8278(02)00036-3

Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC)

U Broome, H Glaumann, Eva Lindström, L Loof, S Almer, Hanne Prytz, H Sandberg-Gertzen, Stefan Lindgren, Thomas Fork, G Jarnerot, R Olsson

Research output: Contribution to journal › Article › peer-review

Abstract

Background/Aims: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). Methods: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. Results: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. Conclusions: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	586-589
Journal	Journal of Hepatology
Volume	36
Issue number	5
DOIs	https://doi.org/10.1016/S0168-8278(02)00036-3
Publication status	Published - 2002

Subject classification (UKÄ)

Gastroenterology and Hepatology

Keywords

cholangiocarcinoma
natural history
ulcerative colitis
liver transplantation

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10.1016/S0168-8278(02)00036-3

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title = "Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC)",

abstract = "Background/Aims: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). Methods: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. Results: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. Conclusions: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.",

keywords = "cholangiocarcinoma, natural history, ulcerative colitis, liver transplantation",

author = "U Broome and H Glaumann and Eva Lindstr{\"o}m and L Loof and S Almer and Hanne Prytz and H Sandberg-Gertzen and Stefan Lindgren and Thomas Fork and G Jarnerot and R Olsson",

year = "2002",

doi = "10.1016/S0168-8278(02)00036-3",

language = "English",

volume = "36",

pages = "586--589",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC)

AU - Broome, U

AU - Glaumann, H

AU - Lindström, Eva

AU - Loof, L

AU - Almer, S

AU - Prytz, Hanne

AU - Sandberg-Gertzen, H

AU - Lindgren, Stefan

AU - Fork, Thomas

AU - Jarnerot, G

AU - Olsson, R

PY - 2002

Y1 - 2002

N2 - Background/Aims: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). Methods: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. Results: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. Conclusions: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.

AB - Background/Aims: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). Methods: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. Results: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. Conclusions: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.

KW - cholangiocarcinoma

KW - natural history

KW - ulcerative colitis

KW - liver transplantation

U2 - 10.1016/S0168-8278(02)00036-3

DO - 10.1016/S0168-8278(02)00036-3

M3 - Article

VL - 36

SP - 586

EP - 589

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 5

ER -

Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC)

Abstract

Subject classification (UKÄ)

Keywords

Access to Document

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Cite this