NDDVD: an integrated and manually curated Neurodegenerative Diseases Variation Database

Yang Yang; Chen Xu; Xingyun Liu; Chao Xu; Yuanyuan Zhang; Li Shen; Mauno Vihinen; Bairong Shen

doi:10.1093/database/bay018

NDDVD: an integrated and manually curated Neurodegenerative Diseases Variation Database

Yang Yang, Chen Xu, Xingyun Liu, Chao Xu, Yuanyuan Zhang, Li Shen, Mauno Vihinen, Bairong Shen

Protein Bioinformatics

Research output: Contribution to journal › Article › peer-review

Abstract

Neurodegenerative diseases (NDDs) are associated with genetic variations including point substitutions, copy number alterations, insertions and deletions. At present, a few genetic variation repositories for some individual NDDs have been created, however, these databases are needed to be integrated and expanded to all the NDDs for systems biological investigation. We here build a relational database termed as NDDVD to integrate all the variations of NDDs using Leiden Open Variation Database (LOVD) platform. The items in the NDDVD are collected manually from PubMed or extracted from the existed variation databases. The cross-disease database includes over 6374 genetic variations of 289 genes associated with 37 different NDDs. The patterns, conservations and biological functions for variations in different NDDs are statistically compared and a user-friendly interface is provided for NDDVD at: http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0.

Original language	English
Article number	bay018
Journal	Database: the journal of biological databases and curation
Volume	2018
DOIs	https://doi.org/10.1093/database/bay018
Publication status	Published - 2018 Jan 1

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Neurosciences

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title = "NDDVD: an integrated and manually curated Neurodegenerative Diseases Variation Database",

abstract = "Neurodegenerative diseases (NDDs) are associated with genetic variations including point substitutions, copy number alterations, insertions and deletions. At present, a few genetic variation repositories for some individual NDDs have been created, however, these databases are needed to be integrated and expanded to all the NDDs for systems biological investigation. We here build a relational database termed as NDDVD to integrate all the variations of NDDs using Leiden Open Variation Database (LOVD) platform. The items in the NDDVD are collected manually from PubMed or extracted from the existed variation databases. The cross-disease database includes over 6374 genetic variations of 289 genes associated with 37 different NDDs. The patterns, conservations and biological functions for variations in different NDDs are statistically compared and a user-friendly interface is provided for NDDVD at: http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0.",

author = "Yang Yang and Chen Xu and Xingyun Liu and Chao Xu and Yuanyuan Zhang and Li Shen and Mauno Vihinen and Bairong Shen",

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T2 - an integrated and manually curated Neurodegenerative Diseases Variation Database

AU - Yang, Yang

AU - Xu, Chen

AU - Liu, Xingyun

AU - Xu, Chao

AU - Zhang, Yuanyuan

AU - Shen, Li

AU - Vihinen, Mauno

AU - Shen, Bairong

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Neurodegenerative diseases (NDDs) are associated with genetic variations including point substitutions, copy number alterations, insertions and deletions. At present, a few genetic variation repositories for some individual NDDs have been created, however, these databases are needed to be integrated and expanded to all the NDDs for systems biological investigation. We here build a relational database termed as NDDVD to integrate all the variations of NDDs using Leiden Open Variation Database (LOVD) platform. The items in the NDDVD are collected manually from PubMed or extracted from the existed variation databases. The cross-disease database includes over 6374 genetic variations of 289 genes associated with 37 different NDDs. The patterns, conservations and biological functions for variations in different NDDs are statistically compared and a user-friendly interface is provided for NDDVD at: http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0.

AB - Neurodegenerative diseases (NDDs) are associated with genetic variations including point substitutions, copy number alterations, insertions and deletions. At present, a few genetic variation repositories for some individual NDDs have been created, however, these databases are needed to be integrated and expanded to all the NDDs for systems biological investigation. We here build a relational database termed as NDDVD to integrate all the variations of NDDs using Leiden Open Variation Database (LOVD) platform. The items in the NDDVD are collected manually from PubMed or extracted from the existed variation databases. The cross-disease database includes over 6374 genetic variations of 289 genes associated with 37 different NDDs. The patterns, conservations and biological functions for variations in different NDDs are statistically compared and a user-friendly interface is provided for NDDVD at: http://bioinf.suda.edu.cn/NDDvarbase/LOVDv.3.0.

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DO - 10.1093/database/bay018

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SN - 1758-0463

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JO - Database: the journal of biological databases and curation

JF - Database: the journal of biological databases and curation

M1 - bay018

ER -

NDDVD: an integrated and manually curated Neurodegenerative Diseases Variation Database

Abstract

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