Nerve compression induces activating transcription factor 3 in neurons and Schwann cells in diabetic rats.

Research output: Contribution to journalArticlepeer-review

Abstract

Expression of transcription factor ATF3 in sensory neurons in dorsal root ganglion and in Schwann cells in sciatic nerve of diabetic (BB and Goto-Kakizaki rats; experimental models of types 1 and 2 diabetes, respectively) and healthy rats were examined by immunocytochemistry after nerve compression (silicone tube) for 3, 6 or 14 days. ATF3-stained sensory neurons in dorsal root ganglia and Schwann cells at compression site were more frequent in diabetic BB rats. Decompression of nerves in Goto-Kakizaki rats did not reduce number of ATF3-stained cells. Diabetes (BB; i.e. type 1) confers on the peripheral nerve an increased susceptibility to nerve compression indicated by an increased expression of stained ATF3 neurons and Schwann cells.
Original languageEnglish
Pages (from-to)987-990
JournalNeuroReport
Volume19
Issue number9
DOIs
Publication statusPublished - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Medical Genetics Unit (013241550), Reconstructive Surgery (013240300), Hand Surgery Research Group (013241910)

Subject classification (UKÄ)

  • Neurosciences

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