Net portal absorption of enterally fed alpha-ketoglutarate is limited in young pigs

BD Lambert, B Stoll, H Niinikoski, Stefan Pierzynowski, DG Burrin

Research output: Contribution to journalArticlepeer-review

Abstract

Our aim was to quantify the intestinal metabolic fate of dietary alpha-ketoglutarate (AKG). Female pigs In = 6; 21 d old) were implanted with arterial, venous, portal and gastric catheters and an ultrasonic portal flow probe and fed a corn and soybean meal-based diet. On (t)he day of the experiment, the pigs received a 4-h intragastric infusion of sodium AKG at a rate equivalent to 0, 2.5, 5 or 10% of dietary intake. The net portal AKG balance of the control and 2.5% treatments did not differ and were not different from zero. However, the net portal AKG balance of both the 5 [163 mumol/(kg (.) h)] and 10% [159 mumol/(kg (.) h)] treatments were greater (P < 0.05) than the control. Despite significant net AKG absorption at the 5 and 10% levels, the net portal appearance represented only 10.8 and 6.7%, respectively, of the enteral input. The net portal appearances of glutamate, glutamine, ammonia and the branched-chain amino acids were not affected by dietary AKG level. We conclude that the absorption of dietary AKG is limited in young pigs and does not change the net portal balance of amino acids or ammonia.
Original languageEnglish
Pages (from-to)3383-3386
JournalJournal of Nutrition
Volume132
Issue number11
Publication statusPublished - 2002

Subject classification (UKÄ)

  • Nutrition and Dietetics

Keywords

  • dicarboxylic acid
  • glutamate dehydrogenase
  • glutamate
  • ammonia
  • transport
  • pigs

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