Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

Hanna Skärstrand; Fariba Vaziri Sani; Ahmed Delli; Carina Törn; Helena Larsson; Sten Ivarsson; Daniel Agardh; Åke Lernmark

doi:10.1111/pedi.12222

Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

Hanna Skärstrand, Fariba Vaziri Sani, Ahmed Delli, Carina Törn, Helena Larsson, Sten Ivarsson, Daniel Agardh, Åke Lernmark

Research output: Contribution to journal › Article › peer-review

Abstract

Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.

Original language	English
Pages (from-to)	621-628
Journal	Pediatric Diabetes
Volume	16
Issue number	8
DOIs	https://doi.org/10.1111/pedi.12222
Publication status	Published - 2015

Subject classification (UKÄ)

Endocrinology and Diabetes
Pediatrics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/pedi.12222

http://www.ncbi.nlm.nih.gov/pubmed/25258030?dopt=Abstract

Cite this

@article{4ee07ccab8894aea8f18aa024f6cd775,

title = "Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.",

abstract = "Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.",

author = "Hanna Sk{\"a}rstrand and {Vaziri Sani}, Fariba and Ahmed Delli and Carina T{\"o}rn and Helena Larsson and Sten Ivarsson and Daniel Agardh and {\AA}ke Lernmark",

year = "2015",

doi = "10.1111/pedi.12222",

language = "English",

volume = "16",

pages = "621--628",

journal = "Pediatric Diabetes",

issn = "1399-543X",

publisher = "John Wiley & Sons Inc.",

number = "8",

}

TY - JOUR

T1 - Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

AU - Skärstrand, Hanna

AU - Vaziri Sani, Fariba

AU - Delli, Ahmed

AU - Törn, Carina

AU - Larsson, Helena

AU - Ivarsson, Sten

AU - Agardh, Daniel

AU - Lernmark, Åke

PY - 2015

Y1 - 2015

N2 - Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.

AB - Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.

U2 - 10.1111/pedi.12222

DO - 10.1111/pedi.12222

M3 - Article

C2 - 25258030

SN - 1399-543X

VL - 16

SP - 621

EP - 628

JO - Pediatric Diabetes

JF - Pediatric Diabetes

IS - 8

ER -

Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

Abstract

Subject classification (UKÄ)

UN SDGs

Access to Document

Fingerprint

Cite this