Abstract
The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.
Original language | English |
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Pages (from-to) | 309-313 |
Journal | Regulatory Peptides |
Volume | 23 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1988 Dec |
Subject classification (UKÄ)
- Pharmacology and Toxicology
Free keywords
- Animals
- Carbachol/pharmacology
- Dose-Response Relationship, Drug
- Electric Stimulation
- Guinea Pigs
- Male
- Muscle Contraction/drug effects
- Muscle, Smooth/drug effects
- Neuropeptide Y/pharmacology
- Trachea/drug effects
- Vagus Nerve/drug effects