Neuropeptide Y: prejunctional inhibition of vagally induced contractions in the guinea pig trachea

L Grundemar, Erik Widmark, B Waldeck, R Håkanson

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.

Original languageEnglish
Pages (from-to)309-313
JournalRegulatory Peptides
Volume23
Issue number3
DOIs
Publication statusPublished - 1988 Dec

Subject classification (UKÄ)

  • Pharmacology and Toxicology

Free keywords

  • Animals
  • Carbachol/pharmacology
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Guinea Pigs
  • Male
  • Muscle Contraction/drug effects
  • Muscle, Smooth/drug effects
  • Neuropeptide Y/pharmacology
  • Trachea/drug effects
  • Vagus Nerve/drug effects

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