Neuropsychological functions predict 1-and 3-year outcome in first-episode psychosis

Rickard Carlsson, H Nyman, G Ganse, J Cullberg

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57 Citations (SciVal)


Objective: To examine neuropsychological performance as a possible predictor of course and outcome in first-episode psychotic (FEP) patients. Method: A group of consecutive FEP patients (n = 120) tested with Wechsler Adult Intelligence Scales-Revised (WAIS-R) at baseline was compared with a healthy group (n = 30) matched for age, education and gender. Relationship between WAIS-R and both Brief Psychiatric Rating Scale and Global Assessment of Function (GAF) ratings were studied at baseline and at 1- and 3-year follow-ups. Results: The performance of FEP patients was significantly lower (P < 0.001) than that of healthy comparison subjects on all WAIS-R subtests except for Information and Comprehension. The WAIS-R scores of patients with schizophrenia syndromes (DSM-IV) were lower than those of patients with non-schizophrenia syndromes on Block Design. Low WAIS-R Full-Scale IQ scores in FEP patients predicted the presence of negative symptoms at 1-year follow-up and of low GAF ratings at 3-year follow-up. Conclusion: Neurocognitive performance at admission appears to predict various aspects of functional outcome in FEP.
Original languageEnglish
Pages (from-to)102-111
JournalActa Psychiatrica Scandinavica
Issue number2
Publication statusPublished - 2006

Subject classification (UKÄ)

  • Psychiatry


  • outcome
  • first-episode
  • cognitive functions
  • neuropsychology
  • episode psychosis
  • schizophrenia


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