Neutron capture imaging of 10B in tissue specimens

Research output: Contribution to journalArticlepeer-review

Abstract

Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for quantitative bio-distribution measurements in tissue samples. In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. Particular attention has been paid to the correlation with the morphology of the specimens and to the altered self-absorption properties due to freeze-drying. A self-absorption correction factor for tumour tissue has been experimentally determined.
Original languageEnglish
Pages (from-to)139-146
JournalRadiotherapy and Oncology
Volume26
Issue number2
DOIs
Publication statusPublished - 1993

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Radiation Physics, Lund (013034000), Pathology, (Lund) (013030000), Neurosurgery (013026000)

Subject classification (UKÄ)

  • Radiology, Nuclear Medicine and Medical Imaging
  • Cancer and Oncology

Free keywords

  • BNCT
  • Glioma
  • Bio-distribution
  • Boron imaging
  • Track-films
  • Self-absorption

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