TY - JOUR
T1 - Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice with Severe Acute Pancreatitis.
AU - Merza, Mohammed
AU - Hartman Magnusson, Hannes
AU - Rahman, Milladur
AU - Hwaiz, Rundk
AU - Zhang, Enming
AU - Renström, Erik
AU - Luo, Lingtao
AU - Mörgelin, Matthias
AU - Regnér, Sara
AU - Thorlacius, Henrik
PY - 2015
Y1 - 2015
N2 - Neutrophils are involved in development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is regulated. In addition to secreting antimicrobial compounds, activated neutrophils eliminate invading microorganisms by expelling nuclear DNA and histones to form extracellular web-like structures called neutrophil extracellular traps (NETs). However, NETs have been reported contribute to organ dysfunction in patients with infectious diseases. We investigated whether NETs contribute to development of AP in mice.
AB - Neutrophils are involved in development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is regulated. In addition to secreting antimicrobial compounds, activated neutrophils eliminate invading microorganisms by expelling nuclear DNA and histones to form extracellular web-like structures called neutrophil extracellular traps (NETs). However, NETs have been reported contribute to organ dysfunction in patients with infectious diseases. We investigated whether NETs contribute to development of AP in mice.
UR - https://www.scopus.com/pages/publications/84952910698
U2 - 10.1053/j.gastro.2015.08.026
DO - 10.1053/j.gastro.2015.08.026
M3 - Article
C2 - 26302488
SN - 1528-0012
VL - 149
SP - 1920
JO - Gastroenterology
JF - Gastroenterology
IS - 7
ER -
